Abstract
Bran is the hard outer layer of cereal grains, rich in a myriad of healthy phytochemicals viz. phenolics, flavonoids, glucans and pigments. Unfortunately, these nutrition-rich components are often discarded during milling out of ignorance, organoleptic reasons and rancidity problems. Knowing the phytochemical constituents and pharmacological profile of bran is expected to give insight to their potential application in promotion of health. This study illustrates the antioxidant and anticancer properties of the cereal bran and its derivatives. The current contribution provides a comprehensive review of the bioactive phytochemical constituents of bran, their extraction techniques, the antioxidant and anticancer properties. The issues associated with bran stabilization in foods and enhancement strategies for extraction and bioavailability of bran nutrients are discussed. Bacteria and yeast fermentation of bran have been observed to improve their nutritional profile. Bran products promise potential applications as nutritional ingredients in functional foods. Leading food manufactures have already started fortifying food products with bran, at the wake of the discovery of its overwhelming health-promoting potentials.
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Aravind N, Sissons M, Egan N, Fellows C (2012) Effect of insoluble dietary fibre addition on technological, sensory, and structural properties of durum wheat spaghetti. Food Chem 130:299–309
Talukder S, Sharma DP (2010) Development of dietary fiber rich chicken meat patties using wheat and oat bran. J Food Sci Technol 47:224–229
Yadav DN, Singh KK, Rehal J (2011) Studies on fortification of wheat flour with defatted rice bran for chapati making. J Food Sci Technol. doi:10.1007/s13197-011-0264-9
Lebesi DM, Tzia C (2011) Effect of the addition of different dietary fiber and edible cereal bran sources on the baking and sensory characteristics of cupcakes. Food Bioprocess Technol 4:710–722
Noaman E, El-Din NKB, Bibars MA, Mossallam AAA, Ghoneum M (2008) Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett 268:348–359
Kaneda I, Kubo F, Sakurai H (2007) Relationship between trace metal concentration and antioxidative activity of ancient rice bran (red and black rice) and a present-day rice bran (Koshihikari). J Trace Elem Med Biol 21:43–51
Renuka RD, Arumughan C (2007) Phytochemical characterization of defatted rice bran and optimization of aprocess for their extraction and enrichment. Bioresour Technol 98:3
Ryan EP, Heuberger AL, Weir TL, Barnett B, Broeckling CD, Prenni JE (2011) Rice bran fermented with Saccharomyces boulardii generates novel metabolite profiles with bioactivity. J Agric Food Chem 59:1862–1870
Awika JM, Rooney LW (2004) Sorghum phytochemicals and their potential impact on human health. Phytochemistry 65:1199–1221
Kong L, Wang Y, Cao Y (2008) Determination of Myo-inositol and d-chiro-inositol in black rice bran by capillary electrophoresis with electrochemical detection. J Food Compos Anal 21:501–504
Lerma-García MJ, Herrero-Martínez JM, Simó-Alfonso EF, Mendonça CRB, Ramis-Ramos G (2009) Composition, industrial processing and applications of rice bran γ-oryzanol. Food Chem 115:389–404
Belefant-Miller H, Grace SC (2010) Variations in bran carotenoid levels within and between rice subgroups. Plant Foods Human Nutr 65:358–363
Kulawinek M, Jaromin A, Kozubek A, Zarnowski R (2008) Alkylresorcinols in selected polish rye and wheat cereals and whole-grain cereal products. J Agric Food Chem 56:7236–7242
Wang J, Cao Y, Wang C, Sun B (2011) Wheat bran xylooligosaccharides improve blood lipid metabolism and antioxidant status in rats fed a high-fat diet. Carbohydr Polym 86:1192–1197
Wang J, Sun B, Cao Y, Song H, Tian Y (2008) Inhibitory effect of wheat bran feruloyl oligosaccharides on oxidative DNA damage in human lymphocytes. Food Chem 109:129–136
Saad N, Esa NM, Ithnin H, Shafie NH (2011) Optimization of optimum condition for phytic acid extraction from rice bran. Afr J Plant Sci 5:168–176
Norazalina S, Norhaizan ME, Hairuszah I, Norashareena MS (2010) Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp Toxicol Pathol 62:259–268
Vucenik I, Shamsuddin AM (2003) Cancer inhibition by inositol hexaphosphate (ip6) and inositol: from laboratory to clinic. J Nutr 133:3778S–3784
Lee M-Y, Lin H-Y, Cheng F, Chiang W, Kuo Y-H (2008) Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachrymal-jobi L. Ma-yuen Stapf) bran. Food Chem Toxicol 46:1933–1939
Manisseri C, Gudipati M (2010) Bioactive xylo-oligosaccharides from wheat bran soluble polysaccharides. LWT Food Sci Technol 43:421–430
Chen H-J, Chung C-P, Chiang W, Li Y-L (2011) Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran. Food Chem 126:1741–1748
Arab F, Alemzadeh I, Maghsoudi V (2011) Determination of antioxidant component and activity of rice bran extract. Scientia Iranica. doi:10.1016/j.scient.2011.09.014
Lai P, Li KY, Lu S, Chen HH (2009) Phytochemicals and antioxidant properties of solvent extracts from Japonica rice bran. Food Chem 117:538–544
Zha X-Q, Wang J-H, Yang X-F, Liang H, Zhao L–L, Bao S-H, Luo J-P, Xu Y–Y, Zhou B–B (2009) Antioxidant properties of polysaccharide fractions with different molecular mass extracted with hot-water from rice bran. Carbohydr Polym 78:57–575
Jang S, Xu Z (2009) Lipophilic and hydrophilic antioxidants and their antioxidant activities in purple rice bran. J Agric Food Chem 57:858–862
Wang J, Sun B, Cao Y, Tian Y, Li X (2008) Optimisation of ultrasound-assisted extraction of phenolic compounds from wheat bran. Food Chem 106:804–810
Wang CH, Chen CR, Wu JJ, Wang LY, Chang CM, Ho WJ (2008) Designing supercritical carbon dioxide extraction of rice bran oil that contain oryzanols using response surface methodology. J Sep Sci 31:1399–1407
Manosroi A, Ruksiriwanich W, Abe M, Sakai H, Manosroi W, Manosroi J (2010) Biological activities of the rice bran extract and physical characteristics of its entrapment in niosomes by supercritical carbon dioxide fluid. J Supercrit Fluids 54:137–144
Das M, Gupat S, Kapoor V, Banerjee R, Bal S (2008) Enzymatic polishing of rice-A new processing technology. LWT Food Sci Technol 41:2079–2084
Wiboonsirikul J, Kimura Y, Megumi Kadota M, Morita H, Tsuno T, Adachi S (2007) Properties of extracts from defatted rice bran by its subcritical water treatment. J Agric Food Chem 55:8759–8765
Inglett GE, Chen D (2011) Antioxidant activity and phenolic content of air-classified corn bran. Cereal Chem 88:36–40
Ismail M, Al-Naqeeb G, bin Mamat WAA, Ahmad Z (2010) Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat’s liver. Nutr Metab 7:23
Zhang MW, Zhang RF, Zhang FX, Liu RH (2010) Phenolic profiles and antioxidant activity of black rice bran of different commercially available varieties. J Agric Food Chem 58:7580–7587
Revilla E, Maria CS, Miramontes E, Bautista J, Garcia-martinez A, Cremades O, Cert R, Parrado J (2009) Nutraceutical composition, antioxidant activity and hypocholesterolemic effect of a water-soluble enzymatic extract from rice bran. Food Res Int 42:387–393
Chotimarkorn C, Benjakul S, Silalai N (2008) Antioxidant components and properties of five long-grained rice bran extracts from commercial available cultivars in Thailand. Food Chem 111:636–641
Kim D, Han GD (2011) Ameliorating effects of fermented rice bran extract on oxidative stress induced by high glucose and hydrogen peroxide in 3T3-L1 adipocytes. Plant foods Hum Nutr 66:285–290
Sairam S, Gopala Krishna AG, Urooj A (2011) Physico-chemical characteristics of defatted rice bran and its utilization in a bakery product. J Food Sci Technol 48:478–483
Wang J, Sun B, Cao Y, Wang C (2010) Wheat bran feruloyl oligosaccharides enhance the antioxidant activity of rat plasma. Food Chem 123:472–476
Yu L, Zhou K, Parry JW (2005) Inhibitory effects of wheat bran extracts on human LDL oxidation and free radicals. LWT 38:463–470
Price RK, Welch RW, Lee-Manion AM, Bradbury I, Strain JJ (2008) Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chem 85:152–157
Martinez-Tome M, Murcia MA, Freha N, Ruggieri S, Jimenez AM, Roses F, Parras P (2004) Evaluation of antioxidant capacity of cereal brans. J Agric Food Chem 52:4690–4699
Escarnot E, Aguedo M, Agneessens R, Wathelet B, Paquot M (2011) Extraction and characterization of water-extractable and water-unextractable arabinoxylans from spelt bran: study of the hydrolysis conditions for monosaccharides analysis. J Cereal Sci 53:45–52
Verma B, Hucl P, Chibbar RN (2008) Phenolic content and antioxidant properties of bran in 51 wheat cultivars. Cereal Chem 85:544–549
Verma B, Hucl P, Chibbar RN (2009) Phenolic acid composition and antioxidant capacity of acid and alkali hydrolysed wheat bran fractions. Food Chem 116:947–954
Hosseinian FS, Mazza G (2009) Triticale bran and straw: potential new sources of phenolic acids, proanthocyanidins, and lignans. J Funct Foods 1:57–64
Abokitse K, Wu M, Bergeron H, Grosse S, Lau PCK (2010) Thermostable feruloyl esterase for the bioproduction of ferulic acid from triticale bran. Appl Microbiol Biotechnol 87:195–203
Ren Y, Yang X, Niu X, Ren G (2011) Chemical characterization of the avenanthramide-rich extract from oat and its effect on d-galactose-induced oxidative stress in mice. J Agric Food Chem 59:206–211
Awika JM, Rooney LW, Ralph D, Waniska RD (2004) Anthocyanins from black sorghum and their antioxidant properties. Food Chem 90:293–301
Nyström L, Mäkinen M, Lampi A-M, Piironen V (2005) Antioxidant activity of steryl ferulate extracts from rye and wheat bran. J Agric Food Chem 53:2503–2510
Korycińska M, Czelna K, Jaromin A, Kozubek A (2009) Antioxidant activity of rye bran alkylresorcinols and extracts from whole-grain cereal products. Food Chem 116:1013–1018
Gliwa J, Gunenc A, Ames N, Willmore WG, Hosseinian FS (2011) Antioxidant activity of alkylresorcinols from rye bran and their protective effects on cell viability of PC-12 AC cells. J Agric Food Chem 59:1473–1482
Zhao Z, Egashira Y, Sanada H (2005) Phenolic antioxidants richly contained in corn bran are slightly bioavailable in rats. J Agric Food Chem 53:5030–5035
Choi SW, Lee SK, Kim EO, Oh JH, Yoon KS, Parris N, Hicks KB, Moreau RA (2007) Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acids. J Agric Food Chem 55:3920–3925
Yao HT, Lin JH, Chiang MT, Chiang W, Luo MN, Lii CK (2011) Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs. J Agric Food Chem 59:4306–4314
Wang L, Huang H, Wei Y, Li X, Chen Z (2009) Characterization and anti-tumor activities of sulphated polysaccharide SRBPS2a obtained from defatted rice bran. Int J Biol Macromol 45:427–431
Kong CKL, Lam WS, Chiu LCM, Ooi VEC, Sun SSM, Wong Y-S (2009) A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem Pharmacol 77:1487–1496
Gollapudi S, Ghoneum M (2008) MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev 32:1–6
Leardkamolkarn V, Thongthep W, Suttiarporn P, Kongkachuichai R, Wongpornchai S, Wanavijitr A (2011) Chemopreventive properties of the bran extracted from a newly-developed Thai rice: the Riceberry. Food Chem 125:978–985
Verschoyle RD, Greaves P, Cai H, Edwards RE, Steward WP, Gescher AJ (2007) Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis. Br J Cancer 96:248–254
Cai H, Al-Fayez M, Tunstall RG, Platton S, Greaves P, Steward WP, Gescher AJ (2005) The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. Mol Cancer Ther 4:1287–1292
Chung SY, Seo YK, Park JM, Seo MJ, Park JK, Kim JW, Park CS (2009) Fermented rice bran downregulates MITF expression and leads to inhibition of alpha-MSH-induced melanogenesis in B16F1 melanoma. Biosci Biotechnol Biochem 73:1704–1710
Seo Y-K, Jung S-H, Song K-Y, Park J-K, Park C-S (2010) Anti-photoaging effect of fermented rice bran extract on UV-induced normal skin fibroblasts. Eur Food Res Technol 231:163–169
Rao AS, Reddy SG, BAbu PP, Reddy AR (2010) The antioxidant and antiproliferative activities of methanolic extracts from Njavara rice bran. BMC Complem Altern Med 10:4
Parrado J, Miramontes E, Jover M, Gutierrez JF, de Tera′ LC, Bautista J (2006) Preparation of a rice bran enzymatic extract with potential use as functional food. Food Chem 98:742–748
Takashima A, Ohtomo M, Kikuchi T, Iwashita J, Abe T (2011) Differentiation- and apoptosis-inducing activities of rice bran extracts in a human colon cancer cell line. J Food Sci Technol. doi:10.1007/s13197-011-0368-2
Zhu Y, Conklin DR, Chen H, Wang L, Sang S (2011) 5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth. Bioorg Med Chem 19:3973–3982
Liu L, Winter KM, Stevenson L, Morris C, Leach DN (2012) Wheat bran lipophilic compounds in vitro anticancer effects. Food Chem 130:156–164
Pajari A-M, Oikarinen S, Grasten S, Mutanen M (2000) Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa. Br J Nutr 84:635–643
Alabaster O, Tang Z, Shivapukar N (1997) Inhibition by wheat bran cereals of the development of aberrant crypt foci and colon tumours. Food Chem Toxicol 35:517–522
Suganya PD, Saravanakumar M, Mohandas S (2011) Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (MCF-7) Int J Br Cancer. doi:10.4061/2011/891481
Suganya PD, Saravanakumar M, Mohandas S (2011) Identification of 3-deoxyanthocyanins from red sorghum (Sorghum bicolor) bran and its biological properties. Afr J Pure Appl Chem 5:181–193
Wu L, Huang Z, Qin P, Yao Y, Meng X, Zou J, Zhu K, Ren G (2011) Chemical characterization of a procyanidin-rich extract from sorghum bran and its effect on oxidative stress and tumor inhibition in vivo. J Agric Food Chem 59:8609–8615
Ciobanu D, Istrati L, Leonte M, Ionaşcu D (2007) Studies regarding bakery products obtaining with barley bran supplement. J Agroaliment Proc Technol 13:249–256
Li SC, Chen CM, Lin SH, Chiang W, Shih CK (2011) Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats. J Sci Food Agric 91:547–552
Chung CP, HS HY, Huang DW, Hsu HH, Lin JT, Shih CK, Chiang W (2010) Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway. J Agric Food Chem 58:7616–7623
Chung CP, Hsu CY, Lin JH, Chiang W, Lin YL (2011) Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines. J Agric Food Chem 59:1185–1194
Lebesi DM, Tzia C (2011) Staling of cereal bran enriched cakes and the effect of an endoxylanase enzyme on the physicochemical and sensorial characteristics. J Food Sci 76:380–387
Mishra R, Sharma HK, Sarkar BC, Charanjiv Singh C (2010) Thermal oxidation of rice bran oil during oven test and microwave heating. J Food Sci Technol. doi:10.1007/s13197-011-0274-7
Latha RB, Nasirullah DR (2011) Physico-chemical changes in rice bran oil during heating at frying temperature. J Food Sci Technol. doi:10.1007/s13197-011-0495-9
Kahlon TS, Smith GE (2004) Rice bran: a health promoting ingredient. Cereal Foods World 49:188–194
Eussen SRBM, Rompelberg CJM, Andersson KE, klungel OH, Hellstrand P, Oste R, van Kranen H, Garssen J (2011) Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr−/− mice. Pharmacol Res 64:36–43
Singh B, Shrama HK, Sarkar BC (2011) Optimization of extraction of antioxidants from wheat bran (Triticum spp.) using response surface methodology. J Food Sci Technol. doi:10.1007/s13197-011-0276-5
Katina K, Laitila A, Juvonen R, Liukkonen KH, Kariluoto S, Piironen V, Landberg R, Aman P, Poutanen K (2007) Bran fermentation as a means to enhance technological properties and bioactivity of rye. Food Microbiol 24:175–186
Anson NM, Havenaar R, Vaes W, Coulier L, Venema K, Selinheimo E, Bast A, Guido RMM, Haenen GRMM (2011) Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men. Food Chem 128:404–409
Hemery YM, Anson NM, Havenaar R, Haenen GRMM, Noort MWJ, Rouau X (2010) Dry-fractionation of wheat bran increases the bioaccessibility of phenolic acids in breads made from processed bran fractions. Food Res Int 43:1429–1438
Schramm R, Abadie A, Hua N, Xu Z, Marybeth Lima M (2007) Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide. J Biol Eng 1:9
Sungsopha J, Moongngarm A, Kanesakoo R (2009) Application of germination and enzymatic treatment to improve the concentration of bioactive compounds and antioxidant activity of rice bran. Austr J Basic Appl Sci 3:3653–3661
Khan SH, Butt MS, Sharif MK, Sameen A, Mumtaz S, Sultan MT (2011) Functional properties of protein isolates extracted from stabilized rice bran by microwave, dry heat, and parboiling. J Agric Food Chem 59:216–2420
Sharma S, Kaur S, Dar BN, Singh B (2011) Storage stability and quality assessment of processed cereal brans. Food Sci Technol. doi:10.1007/s13197-011-0537-3
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Patel, S. Cereal bran: the next super food with significant antioxidant and anticancer potential. Mediterr J Nutr Metab 5, 91–104 (2012). https://doi.org/10.1007/s12349-012-0091-1
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DOI: https://doi.org/10.1007/s12349-012-0091-1