Ancestral diets and modern diseases

  • Maurizio Sudano
  • Franco Gregorio
Original Article


Diet has had a deep and wide-ranging impact on human evolution. Contemporary genome was originally selected for the lifestyle of ancestral humans. Since human genome has little changed since the emergence of behaviourally modern humans, the study of prehistoric hunter–gatherer diet could be regarded as a paradigm for modern humans. The discordance between our ancestral, genetically determined biology and the nutritional and activity patterns of contemporary western populations could be the common soil for the emergence and wide spreading of metabolic disease, such as obesity and T2 diabetes.


Evolutionary medicine Paleo-diet Nutrition Insulin-resistance 


Conflict of interest



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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Servizio di Diabetologia e Malattie metabolicheASUR Marche Z.2 UrbinoUrbinoItaly
  2. 2.Unità Operativa Semplice di Malattie Metaboliche e DiabetologiaOspedale Civile “E. Profili”FabrianoItaly

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