Impact of the Mediterranean diet with and without weight loss on plasma cell adhesion molecule concentrations in men with the metabolic syndrome

  • Caroline Richard
  • Charles Couillard
  • Marie-Michelle Royer
  • Sophie Desroches
  • Patrick Couture
  • Benoît Lamarche
Original Article


No study has yet examined how weight loss specifically modifies the impact of the Mediterranean diet (MedDiet) on plasma cell adhesion molecules (CAM) in men with the metabolic syndrome (MetS). Therefore, this study examined the impact of the MedDiet consumed under controlled feeding conditions, with and without weight loss, on plasma CAM concentrations in men with the MetS. The diet of 26 men (age 24–62 years) with the MetS was first standardized to a North American control diet for 5 weeks followed by a 5-week MedDiet, both under weight-maintaining isocaloric feeding conditions. Participants then underwent a 20-week caloric restriction period that led to a 10.2 ± 2.9% reduction in body weight (p < 0.01), followed by the consumption of an isocaloric weight stable MedDiet for 5 weeks. All foods including red wine were provided during the isocaloric phases of the study. There was no change in the average concentrations of any of the CAM after the MedDiet without weight loss. The MedDiet combined with weight loss reduced plasma CAM concentrations by 10.9% (p < 0.01) compared with the control diet and by 6.8% (p = 0.068) compared with the MedDiet without weight loss. These data suggest that weight loss is required for the MedDiet to improve plasma CAM concentrations over a short period of time in men with the MetS. registration number: NCT00988650.


Mediterranean diet Metabolic syndrome Weight loss Cell adhesion molecules 



We are thankful to Provigo-Loblaws which provided the foods used in the present study through their support of the Chair in Nutrition and Cardiovascular Health. We also thank the staff of the metabolic kitchen from the Institute of Nutraceuticals and Functional Foods of Laval University for their dedicated work during the study. We are grateful to the nurses and the laboratory staff of the Institute of Nutraceuticals and Functional Food for their technical assistance and the expert care provided to the participants. We also express our gratitude to the participants, without whom the study would not have been possible. BL, PC and SD have designed and obtained funding for this study from the Canadian Institutes of Health Research (CIHR MOP-68866). PC was responsible for the screening and medical supervision of the study participants. CR coordinated the clinical study and performed statistical analyses, analyzed the data and wrote the manuscript, which was reviewed critically by all authors. CC is an expert in cell adhesion molecule and provided significant input into the interpretation of the data. MMR was implicated in the clinical study and compiled some of the nutritional data. BL holds a Canada Research Chair in Nutrition and Cardiovascular Health. CC, PC and SD are Research Scholar from the Fonds de la Recherche en Santé du Québec. CC and PC are research scholars.

Conflict of interest

The authors report no conflict of interest in relation with this study.

Supplementary material

12349_2010_29_MOESM1_ESM.doc (66 kb)
Supplementary material 1 (DOC 65 kb)


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Caroline Richard
    • 1
  • Charles Couillard
    • 1
  • Marie-Michelle Royer
    • 1
  • Sophie Desroches
    • 2
  • Patrick Couture
    • 3
  • Benoît Lamarche
    • 1
  1. 1.Institute of Nutraceuticals and Functional FoodsLaval UniversityQuebecCanada
  2. 2.Axe de recherche en transfert des connaissances et évaluation des technologies et des modes d’interventions en santéCHUQ Research CenterQuebecCanada
  3. 3.Lipid Research CenterCHUQ Research CenterQuebecCanada

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