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Efficacy of a red yeast rice based nutraceutical in large subgroups of hypercholesterolemic subjects in every day clinical practice

  • A. F. G. Cicero
  • C. Benvenuti
  • ARMoweb study Group
Original Article

Abstract

To verify the efficacy of a patented proprietary combination of nutraceuticals containing natural hypocholesterolemic and antioxidant agents as red yeast rice extract, policosanols, coenzyme Q10, astaxanthin, and folic acid in the following subgroups of hyperlipidemic subjects: fertile (F) versus menopause (M) women, adults versus elderly (>65 years), lunch versus dinner administration time. A randomised, multicenter study in 411 Italians units compared Armolipid-Rottapharm|Madaus (ARM) one tablet/day plus diet versus diet alone (D) for 16 weeks in hyperlipidemic patients [serum total cholesterol (tot-C) >200 mg/dL or LDL-cholesterol (LDL-C) >150 mg/dL at admission]. Efficacy parameters were measured at baseline and every 4 weeks. In 2,408 eligible subjects, 1,665 adults and 743 elderly, total and LDL-cholesterol were likewise reduced by ARM + D in both age classes and significantly versus D. In 1,246 cases, 302 F and 946 M, tot-C gradually and significantly decreased up to 18.7 and 16.8% in F and M treated groups versus 9% in D group. Similar reduction was observed in LDL-C. In 907 cases, the time of administration of ARM was detailed: 733 received ARM + D at dinner and 174 at lunch. Cholesterolemia improved equally in the two groups. The association of ARM with an appropriate diet is more effective than diet alone in reducing abnormal cholesterolemia, independently from age classes and administration time during the day, supporting its positive use for controlling hypercholesterolemia with a positive impact on CHD prevention in all categories of subjects.

Keywords

Lipid-lowering agents Red yeast rice Diet Menopause Elderly Administration time 

Notes

Acknowledgments

We thank Ibis Informatica for the website and database realization and Angela Ponzoni for the logistic and organizing assistance to the project.

Conflict of interest

Dr. Benvenuti is Medical director of Rottapharm-Madaus that supported the study and produces the tested nutraceutical.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • A. F. G. Cicero
    • 1
    • 3
  • C. Benvenuti
    • 2
  • ARMoweb study Group
  1. 1.GC Descovich Atherosclerosis and Metabolic Disease Study Center; Alma Mater StudiorumUniversity of BolognaBolognaItaly
  2. 2.Medical DepartmentRottapharm|Madaus SpAMonzaItaly
  3. 3.Atherosclerosis and Metabolic Diseases Research Unit, Internal Medicine, Aging and Kidney diseases Department, Sant’Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly

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