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Possible molecular basis of cardioprotective effects of green tea

  • E. Pasini
  • A. Stephanou
  • C. C. Scarabelli
  • G. Corsetti
  • R. Aquilani
  • T. M. Scarabelli
Original Article

Abstract

Clinical data suggest that people who use green tea have a lower cardiovascular risk. However, the exact mechanisms of these cardioprotective effects are unknown. We know that STAT1 plays a critical role in promoting apoptotic cell death and STAT3 may antagonise STAT1 and protect cardiac myocytes from ischaemia/reperfusion (I/R) injury. More recently it has been shown that specific molecules such as epigallocatechin-3-gallate (EGCG), which is present in green tea extract (GTE), have antioxidant properties. Considering that: (i) oxygen free radicals (OFR) are produced during myocardial I/R insult and (ii) OFR are responsible for reperfusion cardiac damage, we therefore investigated whether chronic administration per os of GTE reduced I/R damage in the Langendorff perfused isolated rat heart. In addition we evaluated myocardial content of STAT1 and STAT3 and degree of apoptosis. In Sprague-Dawley isolated hearts, GTE reduced the ischaemic mechanical insult, prolonged STAT3 activation/phosphorylation and reduced STAT1 activation with consequent less cell apoptosis. These results show that chronic treatment with GTE protects the heart from I/R injury. Activation of prosurvival STAT3 over the pro-apoptotic STAT1 could be one of the molecular mechanisms involved in green tea-mediated cardiopretection.

Keywords

Green tea Heart Ischaemia Reperfusion Apoptosis 

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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • E. Pasini
    • 1
  • A. Stephanou
    • 2
  • C. C. Scarabelli
    • 3
  • G. Corsetti
    • 4
  • R. Aquilani
    • 5
  • T. M. Scarabelli
    • 6
  1. 1.“S Maugeri Foundation” IRCCSMedical Center of LumezzaneLumezzane (BS)Italy
  2. 2.Medical Molecular Biology Unit Institute of Child HealthUniversity College LondonLondonUK
  3. 3.VA Ann Arbor Health Care System Division of CardiologyUniversity of MichiganAnn ArborUSA
  4. 4.Division of Human Anatomy Department of Biomedical Sciences and BiotechnologyUniversity of BresciaBresciaItaly
  5. 5.Metabolic Service and Nutritional Pathophysiology S. Maugeri Foundation, IRCCSScientific Institute of MontescanoPaviaItaly
  6. 6.Center for Heart and Vessel Preclinical Studies St. John Hospital and Medical CenterWayne State University School of MedicineDetroitUSA

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