Oxidative state and lipid composition of plasma from overweight and moderately obese women
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To determine the oxidative balance and plasma fatty acid composition of overweight and obese women.
Comparative, descriptive study on 60 overweight or obese (BMI 25–33 kg/m2), normotensive, nondiabetic women and 60 age-matched lean healthy women (BMI < 25 kg/m2).
Plasma lipid, hydroperoxide, and antioxidants levels, fatty acid composition and the susceptibility of lipoproteins to peroxidation.
Compared to the lean control group, the patient group had higher susceptibility of lipoproteins to peroxidation and higher peroxide levels. In contrast, the polyunsaturated fatty acids, in particular the ω-3 species, and the antioxidants were lower in the patient group.
The present study shows that overweight and obese people have oxidative balance impairment. The higher susceptibility of lipoproteins to peroxidation is the probable molecular mechanism that promotes a reduction in high unsaturated (and in particular ω-3) fatty acids, as well as antioxidants in the plasma of the overweight and obese subjects.
KeywordsOver weight Obesity Oxidative stress Lipid peroxidation
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