Abstract
Primary squamous cell carcinoma (SCC) of the liver is an extremely rare disease with a very poor prognosis. An 83-year-old woman was referred to our hospital with left abdominal pain. Laboratory data showed mildly elevated C-reactive protein and biliary enzymes. The tumor markers carcinoembryonic antigen, alpha-fetoprotein, and carbohydrate antigen 19-9 were within normal ranges. Contrast-enhanced computed tomography revealed a 60 mm-sized low-density mass with poor contrast enhancement located in the lateral segment of the liver. The tumor showed low signal on T1-weighted magnetic resonance imaging (MRI) and high signal on T2-weighted MRI. The cytology of bile juice showed no malignant findings. Endoscopic ultrasound-guided fine-needle aspiration biopsy was performed, which was suggestive of primary hepatic SCC. Tumor markers cytokeratin 19 fragment (CYFRA) and SCC-related antigen were elevated, at 25.2 ng/mL and 14.7 ng/mL, respectively. Left lobectomy and hilar lymph node dissection were performed. One month after surgery, the tumor marker values showed a marked decrease of 1.8 ng/mL for CYFRA and 0.3 ng/dL for SCC-related antigen. The patient has been without recurrence for more than one and half year postoperatively. SCC-related antigen and CYFRA were markedly decreased after tumor resection in this case, which may suggest their utility as tumor markers for SCC of liver origin.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by YO, TA, MI, KK, AS, AO, SY, and KH. The first draft of the manuscript was written by YO, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Okuda, Y., Abe, T., Ikeda, M. et al. Curative surgery for primary squamous cell carcinoma of the liver: a rare case study. Clin J Gastroenterol 16, 263–269 (2023). https://doi.org/10.1007/s12328-022-01740-3
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DOI: https://doi.org/10.1007/s12328-022-01740-3