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Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration

Abstract

Gastric linitis plastica is a rare condition characterized by the stiffening and thickening of the gastric wall, presenting a “leather bottle” appearance. It is generally associated with infiltration of poorly differentiated gastric cancer cells, but similar findings can arise due to metastases from other cancers and benign inflammatory processes. Despite advances in imaging modalities, pathological evaluation is required for diagnosis. As endoscopic mucosal biopsies may not be diagnostic, endoscopic ultrasound-guided fine-needle aspiration of the thickened stomach wall presents a potential diagnostic option. We report a case which presented with bilateral ovarian tumors and was ultimately diagnosed as gastric signet-ring cell carcinoma with Krukenberg tumors by endoscopic ultrasound-guided fine-needle aspiration of the stomach wall. The preoperative diagnosis allowed the patient to avoid surgery and to start chemotherapy for gastric cancer. We also review the existing literature on endoscopic ultrasound-guided fine-needle aspiration in the context of gastric linitis plastica.

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TO wrote the manuscript and performed the endoscopic procedure. HS and KF critically reviewed the manuscript. All authors approved the final manuscript.

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Correspondence to Takeshi Okamoto.

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Takeshi Okamoto, Hidekazu Suzuki and Katsuyuki Fukuda declare that they have no conflict of interest.

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Supplementary file1 (MPG 3960 KB) Endoscopic ultrasound-guided fine-needle aspiration of the thickened gastric wall was performed with a 19-gauge needle without complications.

12328_2021_1387_MOESM1_ESM.mpg

Supplementary file1 (MPG 3960 KB) Endoscopic ultrasound-guided fine-needle aspiration of the thickened gastric wall was performed with a 19-gauge needle without complications.

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Okamoto, T., Suzuki, H. & Fukuda, K. Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Clin J Gastroenterol 14, 994–1003 (2021). https://doi.org/10.1007/s12328-021-01387-6

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  • DOI: https://doi.org/10.1007/s12328-021-01387-6

Keywords

  • Gastric cancer
  • Signet-ring cell carcinoma
  • Ovarian tumor
  • Peritoneal carcinomatosis
  • Case report