This paper reports the case of a liver-transplant recipient who was infected with SARS-CoV-2 infection and demonstrated a favorable outcome. With the rapid global spread of COVID-19, reliable evidence is necessary to reach a consensus on COVID-19 treatment in organ transplant recipients including those with liver transplants. Several systematic reviews have summarized several aspects of COVID-19 in transplant recipients of solid organs such liver, kidney, heart, and lung [10,11,12]. Despite the selection and publication biases, these studies have indicated that organ transplant recipients with COVID-19 are at high risk for all major adverse outcomes. Previous reports have suggested that liver-transplant recipients are not at an increased risk of severe pulmonary disease than the general population [6, 13]. Our result also suggests that SARS-CoV-2 infection had a limited impact on liver-transplant recipients. However, liver-transplant recipients under maintenance immunosuppressive therapy are considered to be at a higher risk of severe disease of COVID-19 [14, 15]. This remains controversial, and a comparison of COVID-19 outcomes between transplanted and non-transplanted patients is needed to clarify this issue. The progression of COVID-19 may depend on the condition of liver-transplant recipients. Long-term liver-transplant recipients with metabolic comorbidities appear to have poor outcomes. Thus, > 10 years after transplantation, male sex, age > 65 years, obesity, hypertension, and diabetes might be major risk factors for mortality [13, 16]. In addition, a clinical history of cancer was associated with poor outcomes . Our patient was a young man without complicating diseases but with the two risk factors of male sex, and a history of transplantation (that was performed 15 years previously). The clinical characteristics of liver-transplant recipients from Europe included a median age of 65 years at diagnosis and a median time of 6 years from transplantation to COVID-19 diagnosis . Patients who had undergone liver transplantation a long time ago tended to be older in this cohort, although our patient had undergone liver transplantation 15 years earlier and was only 20 years old at the time of SARS-CoV-2 infection. The pediatric patients appeared to have a less severe clinical course of COVID-19 than adults [18, 19]. Young age would overcome the impact of long duration after transplantation. Thus, the background of the liver-transplant recipients are complex, and the risk factors associated with COVID-19 prognosis should be evaluated carefully for each individual patient.
Liver injury is one of the most common clinical features of COVID-19. Liver injury appears common in patients with more severe SARS-CoV-2 infection and is associated with a higher mortality rate . The risks for liver injury were related to the COVID-19 severity, history of liver disease, older age, and male sex . This patient did not develop severe COVID-19 but presented with liver injury. Contrary to that in previous reports, his liver injury was not associated with disease severity. The mechanisms of hepatic impairment were speculated as the direct effect of the virus, immune reactions, hypoxia, secondary nosocomial infection, or drug-induced liver injury [21, 22]. Specific therapy for COVID-19 and oxygen therapy were not required in our patient despite the tacrolimus treatment, and an over-the-counter medicine for common cold was sufficient. Hypoxia and drug-induced liver injury could be eliminated in the current case. The same dose of tacrolimus was continued, and his tacrolimus trough level was 4.96 ng/mL on day 6 after admission. This immune condition with sufficient tacrolimus level might not cause graft rejection. The lack of liver biopsy and liver imaging studies was because he isolated to avoid secondary infection prevented the definitive diagnosis of liver dysfunction. Thinking terms of process of elimination, we speculate that the liver dysfunction might have been due to the direct effect of the virus in the present patient. The pathogenesis of liver injury with SARS-CoV-2 infection remains unclear, and further investigation on this subject is warranted.
The management of immunosuppressive drugs is a major concern in liver-transplant recipients infected with SARS-CoV-2. The effect of COVID-19 and immunosuppressive drugs on liver-transplant recipients remains unclear. Immunosuppressive drugs are not discontinued in most liver-transplant recipients with COVID-19 infection . Several reports have hypothesized that immunosuppressive drugs may prevent virus replication and protect from the viral-induced cytokine storm that causes severe COVID-19 disease [6, 23]. However, adjustment of immunosuppressive drugs might have changed the fatal outcome by secondary nosocomial infection (15). We considered discontinuation or dose reduction of tacrolimus to prevent the risk of secondary infection. This patient had an incidence of liver dysfunction 2.5 years ago and was suspected to have graft rejection due to poor compliance of tacrolimus. We believe that he had a high risk of rejection and were concerned that insufficient dose of tacrolimus might lead to graft rejection, as observed previously. The effect of immunosuppression on COVID-19 progression would be dependent on the severity of COVID-19 disease and the phase of graft rejection. Considering individual risks, we decided to reduce the dose of tacrolimus but not discontinue it when he developed clinical pulmonary disease. He has not developed clinical pulmonary disease, and his liver function was improved without adjustment in the dose of tacrolimus. Insufficient immunosuppression might cause graft rejection, while excessive immune suppression can lead to nosocomial infections. The strategy for COVID-19 treatment should be decided to consider the balance the risks of graft rejection and nosocomial infections.
Although the relatively small sample size and the bias in patient selection prevent us from drawing definitive conclusion about the impact of SARS-CoV-2 infection in liver-transplant recipients, in this 20-year-old man, history of liver transplantation performed 15 years earlier and the absence of metabolic comorbidities were not associated with severe pulmonary disease with SARS-CoV-2 infection under tacrolimus treatment. The effects of SARS-CoV-2 infection on liver-transplant recipients are not well established, and the establishment of optimal guidelines would require time. Liver-transplant recipients must practice frequent hand washing, mask wearing, and social distancing to prevent SARS-CoV-2 infection. The progression of COVID-19 in liver-transplant recipients would is complex, and the risk of severe COVID-19 should be carefully evaluated in individual patients for optimal treatment strategies.