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Pulmonary lymphangitic carcinomatosis from recurrent gastric cancer 19 years after primary resection: a case report

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Abstract

Pulmonary lymphangitic carcinomatosis is one rare pattern of pulmonary metastases in advanced cancers. Gastric cancer is one of the most common forms of cancer that causes pulmonary lymphangitic carcinomatosis. However, recurrent gastric cancer presenting as pulmonary lymphangitic carcinomatosis after surgery is extremely rare. Furthermore, recurrence is usually observed within 5 years. We present the first case of pulmonary lymphangitic carcinomatosis in a patient with recurrent gastric cancer, 19 years after resection. In patients with a history of gastric cancer and the presence of interstitial shadow, pulmonary lymphangitic carcinomatosis should be considered in the differential diagnosis even if several years have passed since surgery.

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Abbreviations

PLC:

Pulmonary lymphangitic carcinomatosis

CT:

Computed tomography

FDG-PET:

18F- fluorodeoxyglucose positron emission tomography

TBLB:

Transbronchial lung biopsy

References

  1. Bruce DM, Keys SD, Eremin O. Lymphangitis carcinomatosa: a literature review. J R Coll Surg Edinb. 1996;41:7–13.

    CAS  PubMed  Google Scholar 

  2. Thomas A, Lenox R. Pulmonary lymphangitic carcinomatosis as a primary manifestation of colon cancer in a young adult. CMAJ. 2008;179:338–40.

    Article  Google Scholar 

  3. Klimek M. Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970–2018. Postgrad Med. 2019;131:309–18.

    Article  Google Scholar 

  4. Funakoshi T, Yasui H, Boku N, et al. Clinicopathological features and outcomes of gastric cancer patients with pulmonary lymphangitis carcinomatosa. Jpn J Clin Oncol. 2014;44:792–8.

    Article  Google Scholar 

  5. Moon YW, Jeung H-C, Rha SY, et al. Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: a 15-year follow-up study at a single Korean Institute. Ann Surg Oncol. 2007;14:2730–7.

    Article  Google Scholar 

  6. Wu C-W, Lo S-S, Shen K-H, et al. Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer. World J Surg. 2003;27:153–8.

    Article  Google Scholar 

  7. Li JH, Zhang SW, Liu J, et al. Review of clinical investigation on recurrence of gastric cancer following curative resection. Chin Med J (Engl). 2012;125:1479–95.

    Google Scholar 

  8. Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687–97.

    Article  CAS  Google Scholar 

  9. Koga S, Takebayashi M, Kaibara N, et al. Pathological characteristics of gastric cancer that develop hematogenous recurrence, with special reference to the site of recurrence. J Surg Oncol. 1987;36:239–42.

    Article  CAS  Google Scholar 

  10. Kanemitsu Y, Kondo H, Katai H, et al. Surgical resection of pulmonary metastases from gastric cancer. J Surg Oncol. 1998;69:147–50.

    Article  CAS  Google Scholar 

  11. Kong JH, Lee J, Yi CA, et al. Lung metastases in metastatic gastric cancer: Pattern of lung metastases and clinical outcome. Gastric Cancer. 2012;15:292–8.

    Article  Google Scholar 

  12. Moubax K, Wuyts W, Vandecaveye V, et al. Pulmonary lymphangitic carcinomatosis as a primary manifestation of gastric carcinoma in a young adult: a case report and review of the literature. BMC Res Notes. 2012;5:638.

    Article  Google Scholar 

  13. Bhattacharya PK, Jamil M, Khonglah Y, et al. A rare case of pulmonary lymphangitic carcinomatosis in a young adult with carcinoma stomach. J Clin Diagnostic Res 2017; 11: OD7–9.

  14. Khachekian A, Shargh S, Arabian S. Pulmonary lymphangitic carcinomatosis from metastatic gastric adenocarcinoma: case report. J Am Osteopath Assoc. 2015;115:332–7.

    PubMed  Google Scholar 

  15. Gleason JB. Lymphangitic Pulmonary Metastasis: A Rare Finding in Gastric Carcinoma. J Clin Diagn Res. 2017;11:25809.

    Google Scholar 

  16. Koma Y, Matsuoka H, Ryoke T, et al. A case of pulmonary carcinomatous lymphangitis and multiple pulmonary infarctions from gastric cancer. Nihon Kokyuki Gakkai Zasshi. 2011;49:577–82.

    PubMed  Google Scholar 

  17. Belhassine M, Papakrivopoulou E, Venet C, et al. Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis. J Gastrointest Oncol. 2018;9:1207–12.

    Article  Google Scholar 

  18. Shiraishi N, Inomata M, Osawa N, et al. Early and late recurrence after gastrectomy for gastric carcinoma. Cancer. 2000;89:255–61.

    Article  CAS  Google Scholar 

  19. Lee JH, Kim H Il, Kim MG, et al. Recurrence of gastric cancer in patients who are disease-free for more than 5 years after primary resection. Surg (United States) 2016; 159: 1090–8.

  20. Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007;7:834–46.

    Article  CAS  Google Scholar 

  21. Paez D, Labonte MJ, Bohanes P, et al. Cancer dormancy: a model of early dissemination and late cancer recurrence. Clin Cancer Res. 2012;18:645–53.

    Article  Google Scholar 

  22. Takeoka Y, Kajihara K, Kusaba T, et al. A case of bone and bone marrow metastases 14 years after gastric cancer surgery. Nihon Rinsho Geka Gakkai Zasshi J Japan Surg Assoc. 2014;75:2757–62 (in Japanese).

    Article  Google Scholar 

  23. Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9:215–21.

    Article  CAS  Google Scholar 

  24. Boku N, Yamamoto S, Fukuda H, et al. Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study. Lancet Oncol. 2009;10:1063–9.

    Article  CAS  Google Scholar 

  25. Okamoto E, Takagi K, Tamura A, et al. A case of advanced gastric cancer with carcinomatous lymphangitis of the lung treated with docetaxel and S-1 combination chemotherapy. Gan To Kagaku Ryoho (Cancer & chemotherapy) 2013 (in Japanese).

  26. Daimon Y, Takahashi M, Yabuno T, et al. A case report of bi-weekly docetaxel and S-1 combination chemotherapy for gastric cancer with carcinomatous lymphangitis of the lung. Nihon Shokakibyo Gakkai Zasshi Japanese J Gastroenterol. 2011;108:605–10 (in Japanese).

    Google Scholar 

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Authors and Affiliations

  1. Department of Respiratory Internal Medicine, Innoshima Ishikai Hospital, 1962 Innoshima-Nakanosho, Onomichi, 722-7221, Japan

    Sachiko Shioya

  2. Department of Respiratory Internal Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Takeshi Masuda, Hiroshi Iwamoto, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka, Hironobu Hamada & Noboru Hattori

Authors
  1. Sachiko Shioya
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  2. Takeshi Masuda
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  3. Hiroshi Iwamoto
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  4. Kakuhiro Yamaguchi
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  5. Shinjiro Sakamoto
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  6. Yasushi Horimasu
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  7. Shintaro Miyamoto
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  8. Taku Nakashima
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  9. Kazunori Fujitaka
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  10. Hironobu Hamada
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  11. Noboru Hattori
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Corresponding author

Correspondence to Takeshi Masuda.

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Conflict of interest

Noboru Hattori has received lecture fees, honoraria from Pfizer. Sachiko Shioya, Takeshi Masuda, Hiroshi Iwamoto, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka and Hironobu Hamada declare that they have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Shioya, S., Masuda, T., Iwamoto, H. et al. Pulmonary lymphangitic carcinomatosis from recurrent gastric cancer 19 years after primary resection: a case report. Clin J Gastroenterol 14, 484–488 (2021). https://doi.org/10.1007/s12328-020-01315-0

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  • DOI: https://doi.org/10.1007/s12328-020-01315-0

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