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Hepatitis A virus infection in an HIV-positive man with previously confirmed immunity against hepatitis A virus

Clinical Journal of Gastroenterology volume 13, pages 844–846 (2020)Cite this article

Abstract

A Japanese man with human immunodeficiency virus (HIV) was detected 9 years ago to have a positive titer for hepatitis A virus (HAV) immunoglobulin (Ig) G, without a history of HAV infection or vaccination. His plasma HIV RNA was well-controlled on antiretroviral therapy for more than 6 years. He developed HAV infection with subsequent reduction of the HAV IgG titer. A decreasing HAV IgG in persons living with HIV might indicate the possibility of HAV reinfection and should prompt the consideration for additional vaccination.

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References

  1. Freidl GS, Sonder GJ, Bovée LP, et al. Hepatitis A outbreak among men who have sex with men (MSM) predominantly linked with the EuroPride, the Netherlands, July 2016 to February 2017. Euro Surveill. 2017;22:30468.

    Article  Google Scholar 

  2. Chen NY, Liu ZH, Shie SS, et al. Clinical characteristics of acute hepatitis A outbreak in Taiwan, 2015–2016: observations from a tertiary medical center. BMC Infect Dis. 2017;17:441.

    Article  Google Scholar 

  3. CDC. Widespread outbreaks of hepatitis A across the United States. https://www.cdc.gov/hepatitis/outbreaks/2017March-HepatitisA.htm. Accessed 26 July 2019.

  4. Charre C, Ramière C, Roque-Afonso AM, et al. Hepatitis A outbreak in HIV-infected MSM and in PrEP-using MSM despite a high level of immunity, Lyon, France, January to June 2017. Euro Surveill. 2017;22:17–007422017.

    Article  Google Scholar 

  5. Lee HJV, Jeong HS, Cho BK, et al. Evaluation of an immunochromatographic assay for the detection of anti-hepatitis A virus IgM. Virol J. 2010;7:164.

    Article  Google Scholar 

  6. Lee MJ, Douthwaite S, Kulasegaram R. Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual. Sex Transm Infect. 2018;94:30–1.

    Article  Google Scholar 

  7. Gallego M, Robles M, Palacios R, et al. Impact of acute hepatitis A virus (HAV) infection on HIV viral load in HIV-infected patients and influence of HIV infection on acute HAV infection. J Int Assoc Physicians AIDS Care (Chic). 2011;10:40–2.

    CAS  Article  Google Scholar 

  8. Solen K, Odile L, Clément T, et al. Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis. Clin Infect Dis. 2014;58:1130–9.

    Article  Google Scholar 

  9. DeGroote NP, Mattson CL, Tie Y, et al. Hepatitis A virus immunity and vaccination among at-risk persons receiving HIV medical care. Prev Med Rep. 2018;11:139–44.

    Article  Google Scholar 

  10. Brennan J, Moore K, Sizemore L, et al. Notes from the field: acute hepatitis A virus infection among previously vaccinated persons with HIV infection—tennessee, 2018. MMWR Morb Mortal Wkly Rep. 2019;68:328–9.

    Article  Google Scholar 

  11. Fritzsche C, Bergmann L, Loebermann M, et al. Immune response to hepatitis A vaccine in patients with HIV. Vaccine. 2019;37:2278–83.

    CAS  Article  Google Scholar 

  12. EACS: European AIDS Clinical Society. EACS Guidelines Version 9.1—October 2018. European AIDS Clinical Society (EACS); 2018. https://www.eacsociety.org/guidelines/eacs-guidelines/eacs-guidelines.html. Accessed 26 July 2019.

  13. CDC. ACIP Recommendations. https://www.cdc.gov/vaccines/acip/recommendations.html. Accessed 26 July 2019.

  14. Valota M, Thienemann F, Misselwitz B. False-positive serologies for acute hepatitis A and autoimmune hepatitis in a patient with acute Epstein-Barr virus infection. BMJ Case Rep. 2019;12:pii: e228356.

    Article  Google Scholar 

  15. De Milito A, Nilsson A, Titanji K, et al. Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection. Blood. 2004;103:2180–6.

    Article  Google Scholar 

  16. Gray JR, Steinbrecher UP. False positive anti-hepatitis A virus IgM result in a patient with autoimmune hepatitis. Can J Gastroenterol. 1989;3:115–8.

    Article  Google Scholar 

  17. Alatoom A, Ansari MQ, Cuthbert J. Multiple factors contribute to positive results for hepatitis A virus immunoglobulin M antibody. Arch Pathol Lab Med. 2013;137:90–5.

    CAS  Article  Google Scholar 

  18. Abbott Japan Co., Ltd. Package insert: HAVAB-G. https://www.info.pmda.go.jp/tgo/pack/21800AMY10040000_A_01_07/. In Japanese. Accessed 26 July 2019.

  19. Park GC, Hwang S, Yu YD, et al. Intractable recurrent hepatitis A virus infection requiring repeated liver transplantation: a case report. Transplant Proc. 2010;42:4658–60.

    CAS  Article  Google Scholar 

  20. Eisenbach C, Longerich T, Fickenscher H, et al. Recurrence of clinically significant hepatitis A following liver transplantation for fulminant hepatitis A. J Clin Virol. 2006;35:109–12.

    Article  Google Scholar 

  21. Inoue K, Yoshiba M, Yotsuyanagi H, et al. Chronic hepatitis A with persistent viral replication. J Med Virol. 1996;50:322–4.

    CAS  Article  Google Scholar 

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Acknowledgements

We appreciate Shuzo Usuku for molecular analysis.

Author information

Affiliations

  1. Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555, Japan

    Yukihiro Yoshimura, Hiroshi Horiuchi, Nobuyuki Miyata & Natsuo Tachikawa

  2. Kanagawa Prefectural Institute of Public Health, 1-3-1 Shimoya-cho, Chigasaki, Kanagawa, 253-0087, Japan

    Makiko Kondo

Authors
  1. Yukihiro Yoshimura
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  2. Hiroshi Horiuchi
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  3. Nobuyuki Miyata
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  4. Makiko Kondo
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  5. Natsuo Tachikawa
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Contributions

All authors meet the ICMJE authorship criteria. All authors contributed to the study conception and design. Material preparation was performed by MK, data collection and analysis were performed by YY. The first draft of the manuscript was written by YY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yukihiro Yoshimura.

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The authors declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

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Informed consent was obtained from the patient to be included in the study.

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Yoshimura, Y., Horiuchi, H., Miyata, N. et al. Hepatitis A virus infection in an HIV-positive man with previously confirmed immunity against hepatitis A virus. Clin J Gastroenterol 13, 844–846 (2020). https://doi.org/10.1007/s12328-020-01102-x

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  • DOI: https://doi.org/10.1007/s12328-020-01102-x

Keywords

  • Hepatitis A
  • HIV
  • Immunoglobulin
  • Reinfection