Hepatocellular metastasis recurrence in liver transplant after treatment with direct antiviral agents

  • Silvia Maier
  • Debora Donnini
  • Laura De Luca
  • Claudio Avellini
  • Leonardo Alberto Sechi
  • Giorgio SoardoEmail author
Case Report


Chronic HCV liver infection is considered one of the main causes of liver cirrhosis and hepatocellular carcinoma (HCC). For a selected group of patients, orthotopic liver transplantation (OLTx) is the most effective option to cure both liver diseases. After liver transplantation, patients may be at risk of viral infection reactivation and HCC recurrence. HCV recurrence on the transplanted organ can lead to graft cirrhosis and therefore the clearance of virus with antiviral therapies has a pivotal role on the prevention of graft damage. Nowadays, direct antiviral agents (DAAs) represent the choice treatment for HCV recurrence in liver transplanted patients, ensuring high eradication rates. We present the case of a liver transplant recipient who developed, 7 years after OLTx and immediately after a DAAs treatment, a subcutaneous abdominal mass with histological characteristics of HCC.


Hepatocellular carcinoma metastasis Orthotopic liver transplantation Hepatitis C infection Direct antiviral agents 


Compliance with ethical standards

Conflict of interest

All the authors declare they have no conflict of interest.

Human rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  1. 1.Liver Unit, Internal Medicine, Department of Medicine (DAME)University School of Medicine of UdineUdineItaly
  2. 2.Department of Laboratory Medicine, Institute of Pathological AnatomyUniversity School of Medicine of UdineUdineItaly

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