Guillain–Barré syndrome: rare extra-intestinal manifestation of hepatitis B

  • Amey Dilip Sonavane
  • Sanjiv Saigal
  • Abhishek Kathuria
  • Narendra S. Choudhary
  • Neeraj Saraf
Case Report


Extrahepatic syndromes are uncommon manifestations of acute and chronic hepatitis B. The pathogenesis likely involves an aberrant immunologic response to extrahepatic viral proteins. Antiviral therapy reduces the availability of these viral protein antigens and thus halts immune activation. Approximately 1% of all cases of acute inflammatory demyelinating polyneuropathy are associated with hepatitis B. Guillain–Barre syndrome (GBS) is a remarkably clinically diverse disorder with distinctive variants characterised by an immune-mediated attack to components of the peripheral nervous system. In this report, we present a rare case of GBS with chronic hepatitis B that resolved with antiviral and intravenous immunoglobulin therapy.


Guillain–Barré syndrome Hepatitis B Extrahepatic syndrome 


Compliance with ethical standards

Conflict of interest

Dr. Amey Sonavane, Dr. Sanjiv Saigal, Dr. Abhishek Kathuria, Dr. Narendra Singh Choudhary, Dr. Neeraj Saraf have no conflict of interest.

Human rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from the patient for being included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  • Amey Dilip Sonavane
    • 1
  • Sanjiv Saigal
    • 1
  • Abhishek Kathuria
    • 1
  • Narendra S. Choudhary
    • 1
  • Neeraj Saraf
    • 1
  1. 1.Department of Liver Transplantation and Regenerative MedicineMedanta - the MedicityGurugramIndia

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