Clinical Journal of Gastroenterology

, Volume 11, Issue 2, pp 103–112 | Cite as

Current treatment paradigms in pediatric short bowel syndrome

  • Raghav Chandra
  • Anil Kesavan
Clinical Review


Pediatric short bowel syndrome (SBS) is a serious condition which occurs in children with congenital or acquired reduction in length of the small intestine. SBS results in excessive fluid loss, nutrient malabsorption, electrolyte abnormalities, increased susceptibility to infections, parenteral nutrition associated complications and affects weight gain and growth. In children, SBS is debilitating and uniformly fatal without treatment. The primary goal of treatment is to restore enteral autonomy and reduce long-term dependence on parenteral support by increasing the absorptive potential of the remnant intestine. In this review, the medical and surgical management of SBS including pharmacologic agents, parenteral nutrition, dietary strategies, surgical lengthening procedures, and small bowel transplant will be discussed.


Pediatric short bowel syndrome Intestinal rehabilitation Intestinal adaptation Surgical lengthening procedures Small bowel transplantation 



Short bowel syndrome


Parenteral nutrition


Necrotizing enterocolitis


Small intestinal bacterial overgrowth


Glucagon-like peptide-2


Long-chain triglycerides


Medium-chain triglycerides




Intensive care unit


Deep venous thrombosis


Intestinal failure-associated liver disease




Longitudinal intestinal lengthening and tailoring


Serial transverse enteroplasty


segmental reversal of the small bowel


Small bowel transplantation


Acute cellular rejection


Graft vs. host disease


Post-transplant lymphoproliferative disease




Epstein-Barr virus


Author contributions

All authors influenced the concept, wrote and revised the manuscript and approved of the final version.


The authors received no financial support for the research, authorship, and/or publication of this article.

Compliance with ethical standards

Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Human rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Japanese Society of Gastroenterology 2017

Authors and Affiliations

  1. 1.Doctor of Medicine (MD) ProgramRush Medical CollegeChicagoUSA
  2. 2.Section of Pediatric GastroenterologyRush University Medical CenterChicagoUSA

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