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Hepatitis A virus genotype IA-infected patient with marked elevation of aspartate aminotransferase levels

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Abstract

We describe a case of acute liver failure (ALF) without hepatic encephalopathy with marked elevation of aminotransferase due to hepatitis A, according to the revised Japanese criteria of ALF. This liver biopsy of the patient showed compatible to acute viral hepatitis and she immediately recovered without intensive care. She had no comorbid disorders. Of interest, phylogenetic tree analysis using almost complete genomes of hepatitis A virus (HAV) demonstrated that the HAV isolate from her belonged to the HAV subgenotype IA strain and was similar to the HAJFF-Kan12 strain (99% nucleotide identity) or FH1 strain (98% nucleotide identity), which is associated with severe or fulminant hepatitis A. Careful interpretation of the association between HAV genome variations and severity of hepatitis A is needed and the mechanism of the severe hepatitis should be explored.

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Acknowledgements

This work was partly supported by the grants from the Japan Agency for Medical Research and Development (AMED).

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Authors and Affiliations

  1. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Yoshifumi Miura, Tatsuo Kanda, Shin Yasui, Koji Takahashi, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Makoto Arai & Osamu Yokosuka

  2. Department of Molecular Virology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Shingo Nakamoto

  3. Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Tsutomu Nishizawa & Hiroaki Okamoto

Authors
  1. Yoshifumi Miura
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  2. Tatsuo Kanda
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  3. Shin Yasui
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  4. Koji Takahashi
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  7. Masato Nakamura
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  8. Shuang Wu
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  9. Shingo Nakamoto
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  11. Tsutomu Nishizawa
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  13. Osamu Yokosuka
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Corresponding author

Correspondence to Tatsuo Kanda.

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All authors declare that they have no conflict of interest.

Human/animal rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from the patient in the report.

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Miura, Y., Kanda, T., Yasui, S. et al. Hepatitis A virus genotype IA-infected patient with marked elevation of aspartate aminotransferase levels. Clin J Gastroenterol 10, 52–56 (2017). https://doi.org/10.1007/s12328-016-0700-5

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  • DOI: https://doi.org/10.1007/s12328-016-0700-5

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