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Helicobacter pylori-negative gastric cancer: advanced-stage undifferentiated adenocarcinoma located in the pyloric gland area

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Abstract

The incidence of Helicobacter pylori-negative gastric cancer (HpNGC) is extremely low. A 78-year old female without H. pylori infection was diagnosed with type 4 advanced-stage gastric prepylorus cancer. Distal gastrectomy was performed as for HpNGC (cT3N0M0). Histological findings of the resected specimen showed poorly differentiated adenocarcinoma and signet ring cell carcinoma, which were located in the pyloric gland area, diffusely invaded beyond the serosa without lymph node metastasis (pT4aN0M0). Most cases of undifferentiated-type HpNGC are diagnosed in the early stage and are located in the fundic gland area. We report the first case of advanced-stage undifferentiated HpNGC located in the pyloric gland area.

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Authors and Affiliations

  1. Department of Gastroenterology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 632-8552, Japan

    Akihiro Okano & Masaya Ohana

  2. Department of Gastroenterological Surgery, Tenri Hospital, Tenri, Japan

    Shigeru Kato

Authors
  1. Akihiro Okano
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  2. Shigeru Kato
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  3. Masaya Ohana
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Correspondence to Akihiro Okano.

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Conflict of interest:

Akihiro Okano, Shigeru Kato, and Masaya Ohana declare that they have no conflict of interest.

Human Rights:

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed Consent:

Informed consent was obtained from all patients for being included in the study.

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Okano, A., Kato, S. & Ohana, M. Helicobacter pylori-negative gastric cancer: advanced-stage undifferentiated adenocarcinoma located in the pyloric gland area. Clin J Gastroenterol 10, 13–17 (2017). https://doi.org/10.1007/s12328-016-0696-x

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  • DOI: https://doi.org/10.1007/s12328-016-0696-x

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