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A case of simultaneous esophageal squamous cell carcinoma and Barrett’s adenocarcinoma

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Abstract

A 77-year-old male with a long history of alcohol consumption and smoking was admitted for hoarseness and dysphagia. Computed tomography revealed thickening of the middle intrathoracic esophageal wall and multiple mediastinal lymph node swellings. Esophagogastroduodenoscopic examination disclosed an advanced-stage squamous cell carcinoma lesion in the middle intrathoracic esophagus with synchronous early stage Barrett’s adenocarcinoma. The patient underwent endoscopic submucosal dissection for the adenocarcinoma followed by chemoradiation therapy for the squamous cell carcinoma. In spite of their common risk factors, the simultaneous manifestation of esophageal squamous cell carcinoma and Barrett’s adenocarcinoma is extremely rare and requires further study.

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References

  1. Tachimori Y, Ozawa S, Fujishiro M, et al. Comprehensive registry of esophageal cancer in Japan 2006. Esophagus. 2014;11:21–47.

    Article  Google Scholar 

  2. Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 2009;44:518–34.

    Article  PubMed  Google Scholar 

  3. Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á, et al. Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 2015;21(26):7933–43.

    PubMed  PubMed Central  Google Scholar 

  4. de Jonge PJ, van Blankenstein M, Grady WM, et al. Barrett’s oesophagus: epidemiology, cancer risk and implications for management. Gut. 2014;63(1):191–202.

    Article  PubMed  Google Scholar 

  5. Sharma P, Dent J, Armstrong D, et al. The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria. Gastroenterology. 2006;131:1392–9.

    Article  PubMed  Google Scholar 

  6. Yagi K, Nakamura A, Sekine A. Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylory infection. J Gastroenterol Hepatol. 2002;17:39–45.

    Article  PubMed  Google Scholar 

  7. The Japan Esophageal Society: Japanese Classification of Esophageal Cancer. 10th ed. Tokyo: Kanehara Shuppan; 2008

  8. Pennathur A, Gibson MK, Jobe BA, et al. Oesophageal carcinoma. Lancet. 2013;381(9864):400–12.

    Article  PubMed  Google Scholar 

  9. Hongo M, Nagasaki Y, Shoji T. Epidemiology of esophageal cancer: orient to occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol. 2009;24:729–35.

    Article  PubMed  Google Scholar 

  10. Ariella M, Rosengard AM, Hamilton SR. Squamous carcinoma of the esophagus in patients with Barrett esophagus. Mod Pathol. 1989;2(1):2–7.

    Google Scholar 

  11. Allan NK, Weitzner S, Scott L, et al. Adenocarcinoma arising in Barrett’s esophagus with synchronous squamous cell carcinoma of the esophagus. South Med J. 1986;79(8):1036–9.

    Article  CAS  PubMed  Google Scholar 

  12. Sheahan DG, Berman MA. Barrett’s mucosa with multiple carcinomas of the esophagus and oral cavity. J Clin Gastroenterol. 1986;8(1):103–7.

    Article  CAS  PubMed  Google Scholar 

  13. Geramizadeh B, Safari A, Javadi F, et al. Squamous cell carcinoma of the esophagus and adenocarcinoma of gastroesophageal junction, a rare coincidence. Iran Red Crescent Med J. 2011;13(7):507–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Dunbar KB, Spechler SJ. The risk of lymph-node metastases in patients with high-grade dysplasia or intramucosal carcinoma in Barrett’s esophagus: a systematic review. Am J Gastroenterol. 2012;107(6):850–62.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Yokoyama T, Yokoyama A, Kato H, et al. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer epidemiol Biomarker Prev. 2003;12:1227–33.

    CAS  Google Scholar 

  16. Corley DA, Kubo A, Levin TR, et al. Helicobacter pylori infection and the risk of Barrett’s oesophagus: a community-based study. Gut. 2008;57(6):727–33.

    Article  CAS  PubMed  Google Scholar 

  17. Bollschweiler E, Schloesser T, Leers J, et al. High prevalence of colonic polyps in white males with esophageal adenocarcinoma. Dis Colon Rectum. 2009;52(2):299–304.

    Article  PubMed  Google Scholar 

  18. Balasubramanian G, Gupta N, Giacchino M, et al. Cigarette smoking is a modifiable risk factor for Barrett’s oesophagus. United Eur Gastroenterol J. 2013;1(6):430–7.

    Article  Google Scholar 

  19. Toh Y, Oki E, Ohgaki K, et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Int J Clin Oncol. 2010;15(2):135–44.

    Article  CAS  PubMed  Google Scholar 

  20. Thrift AP, Cook MB, Vaughan TL, et al. Alcohol and the risk of Barrett’s esophagus:a pooled analysis from the International BEACON consortium. Am J Gastroenterol. 2014;109:1586–94.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Iijima K, Koike T, Abe Y, et al. Extensive gastric atrophy:an increased risk factor of superficial esophageal squamous cell carcinoma in Japan. Am J Gastroenterol. 2007;102:1603–9.

    Article  PubMed  Google Scholar 

  22. Anderson LA, Murphy SJ, Johnson BT, et al. Relationship between Helicobacter pylory infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence:results from the FINBAR case–control study. Gut. 2008;57:734–9.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Yugo Iwaya.

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Conflict of Interest:

Tomoo Yamazaki, Yugo Iwaya, Mai Iwaya, Takayuki Watanabe, Ayako Seki, Yasuhide Ochi, Etsuo Hara, Tomohiro Sekiguchi, Noriko Hosaka, Norikazu Arakura, Eiji Tanaka and Osamu Hasebe declare that they have no conflict of interest.

Human Rights:

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Yamazaki, T., Iwaya, Y., Iwaya, M. et al. A case of simultaneous esophageal squamous cell carcinoma and Barrett’s adenocarcinoma. Clin J Gastroenterol 9, 222–227 (2016). https://doi.org/10.1007/s12328-016-0653-8

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  • DOI: https://doi.org/10.1007/s12328-016-0653-8

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