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Lethal hemorrhage from duodenal ulcer due to small pancreatic cancer

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Abstract

Gastrointestinal massive arterial hemorrhage is difficult to stop endoscopically, especially from a duodenal ulcer (DU), because of the anatomically narrow lumen. Here we report a rare case of small pancreatic cancer-induced lethal hemorrhagic DU. The 69-year-old patient was transferred due to massive hematemesis, hypotension and loss of consciousness. Emergency upper endoscopy revealed a DU with active bleeding from an unclear hemorrhagic spot, which stopped transiently by itself. Subsequently he began to vomit blood again and angiography showed extravasation from the gastroduodenal artery (GDA). Hemostasis by transcatheter arterial embolization (TAE) was achieved but the patient unfortunately died soon after because of hemorrhagic shock (10 h after his first hematemesis). The autopsy revealed a small pancreatic cancer (poorly differentiated adenocarcinoma, 10 × 25 mm in size) infiltrating into one-half of the penetrating DU with a nearby ruptured GDA wall, suggesting that the DU was caused by the pancreatic cancer. Our 7-year analysis of emergency endoscopies in our department for upper gastrointestinal bleeding revealed that TAE was performed in more cases of duodenal hemorrhage (5.7 %) than stomach hemorrhage (1.8 %), showing the difficulty in stopping hemorrhage from DU endoscopically. This case raises the possibility that intractable lethal hemorrhagic DU could be caused by a very small pancreatic tumor.

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Authors and Affiliations

  1. Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan

    Masaaki Higashiyama, Hirohisa Suzuki, Chikako Watanabe, Kengo Tomita, Shunsuke Komoto, Shigeaki Nagao, Soichiro Miura & Ryota Hokari

  2. Department of Laboratory Medicine, National Defense Medical College Hospital, 3-2 Namiki, Tokorozawa, 359-8513, Japan

    Kuniaki Nakanishi

Authors
  1. Masaaki Higashiyama
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  2. Hirohisa Suzuki
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  3. Chikako Watanabe
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  4. Kengo Tomita
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  5. Shunsuke Komoto
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  6. Shigeaki Nagao
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  7. Kuniaki Nakanishi
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  8. Soichiro Miura
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  9. Ryota Hokari
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Correspondence to Masaaki Higashiyama.

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Conflict of Interest:

Masaaki Higashiyama, Hirohisa Suzuki, Chikako Watanabe, Kengo Tomita, Shunsuke Komoto, Shigeaki Nagao, Kuniaki Nakanishi, Soichiro Miura and Ryota Hokari declare that they have no conflict of interest.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

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Informed consent was obtained from all patients for being included in the study.

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Higashiyama, M., Suzuki, H., Watanabe, C. et al. Lethal hemorrhage from duodenal ulcer due to small pancreatic cancer. Clin J Gastroenterol 8, 236–239 (2015). https://doi.org/10.1007/s12328-015-0586-7

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  • DOI: https://doi.org/10.1007/s12328-015-0586-7

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