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Innate immunity and inflammatory bowel disease: a review of clinical evidence and future application

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Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder caused by dysregulated immune responses in a genetically predisposed individual. Recent accumulating data, including genome-wide association studies, have identified >100 distinct genetic loci that confer susceptibility. We highlight how the dysregulation of host−microbial interaction leads to intestinal inflammation, particularly with respect to the overlap of common genetic and pathophysiological mechanisms of IBD.

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Disclosures

Conflict of Interest: The authors declare that they have no conflict of interest.

Human/Animal Rights: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent: Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan

    Kyoko Katakura, Hiroshi Watanabe & Hiromasa Ohira

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  1. Kyoko Katakura
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  2. Hiroshi Watanabe
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  3. Hiromasa Ohira
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Correspondence to Kyoko Katakura.

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Katakura, K., Watanabe, H. & Ohira, H. Innate immunity and inflammatory bowel disease: a review of clinical evidence and future application. Clin J Gastroenterol 6, 415–419 (2013). https://doi.org/10.1007/s12328-013-0436-4

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  • DOI: https://doi.org/10.1007/s12328-013-0436-4

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