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A case of a large cholangiolocellular carcinoma

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Abstract

Cholangiolocellular carcinoma (CoCC) is a rare malignant primary liver tumor that is considered to originate from the canals of Hering, where hepatic progenitor cells are located. CoCC has various clinicopathological findings, therefore it is difficult to describe a clear diagnostic criteria for CoCC. Reported is a case of a large CoCC in a 45-year-old Japanese woman, which could not be preoperatively diagnosed as CoCC. The final diagnosis of CoCC was determined by pathological observation. Since both the biological behavior and diagnostic criteria of CoCC remain unclear, it is necessary to accumulate more information on CoCCs in order to elucidate these characteristic findings.

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Abbreviations

PT:

Prothrombin time

ICG:

Indocyanine green

References

  1. Shiota K, Taguchi J, Nakashima O, Nakashima M, Kojiro M. Clinicopathologic study on cholangiolocellular carcinoma. Oncol Rep. 2001;8:263–8.

    CAS  PubMed  Google Scholar 

  2. Steiner PE, Higginson J. Cholangiolocellular carcinoma of the liver. Cancer. 1959;12:753–9.

    Article  CAS  PubMed  Google Scholar 

  3. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, et al. The canals of Hering and hepatic stem cells in humans. Hepatology. 1999;30:1425–33.

    Article  CAS  PubMed  Google Scholar 

  4. Durnez A, Verslype C, Nevens F, Fevery J, Aerts R, Pirenne J, et al. The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin. Histopathology. 2006;49:138–51.

    Article  CAS  PubMed  Google Scholar 

  5. Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R, et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008;47:1544–56.

    Article  CAS  PubMed  Google Scholar 

  6. Asayama Y, Tajima T, Okamoto D, Nishie A, Ishigami K, Ushijima Y, et al. Imaging of cholangiolocellular carcinoma of the liver. Eur J Radiol. 2010;75:e120–5.

    Article  PubMed  Google Scholar 

  7. Fukukura Y, Hamanoue M, Fujiyoshi F, Sasaki M, Haruta K, Inoue H, et al. Cholangiolocellular carcinoma of the liver: CT and MR findings. J Comput Assist Tomogr. 2000;24:809–12.

    Article  CAS  PubMed  Google Scholar 

  8. Kanamoto M, Yoshizumi T, Ikegami T, Imura S, Morine Y, Ikemoto T, et al. Cholangiolocellular carcinoma containing hepatocellular carcinoma and cholangiocellular carcinoma, extremely rare tumor of the liver: a case report. J Med Invest. 2008;55:161–5.

    Article  PubMed  Google Scholar 

  9. Motosugi U, Ichikawa T, Nakajima H, Sou H, Sano M, Sano K, et al. Imaging of small hepatic metastases of colorectal carcinoma: how to use superparamagnetic iron oxide-enhanced magnetic resonance imaging in the multidetector-row computed tomography age? J Comput Assist Tomogr. 2009;33:266–72.

    Article  PubMed  Google Scholar 

  10. Libbrecht L, Desmet V, Van Damme B, Roskams T. The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol. 2000;33:76–84.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Kiminori Kimura.

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Kadono, M., Kimura, K., Imamura, J. et al. A case of a large cholangiolocellular carcinoma. Clin J Gastroenterol 4, 340–346 (2011). https://doi.org/10.1007/s12328-011-0250-9

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  • DOI: https://doi.org/10.1007/s12328-011-0250-9

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