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Pathological feature of a giant ileal Meckel’s diverticulum with ectopic gastric mucosa

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Abstract

The ileum generally works well, whereas Meckel’s diverticulum (MD) has complications including bleeding, obstruction, intussusception, diverticulitis, and perforation. Our knowledge of the pathological features of the MD muscular layer and mucosa is limited. We report a rare case of giant MD that was diagnosed by double-balloon enteroscopy (DBE). The pathological features of the mucosa were evaluated by investigation for Helicobacter pylori; and the nuclear proliferation antigen Ki-67, the gastrointestinal cancer-associated biomarker TRAK1, synaptophysin, and neurofilament were used to precisely define the mucosa and neuronal and ganglion cell components. The pathophysiology of MD is discussed and a literature review is presented. We believe that this is the first report of a systematic histochemical analysis of the mucosa and myenteric plexus of MD and the normal ileum. The present investigation may provide novel evidence of pathological abnormalities resulting in the complex complications of MD.

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Acknowledgments

We thank Ms Marian Tombs at Johns Hopkins Hospital (Baltimore, Maryland) for critical proofreading of the manuscript and providing suggestions for revision. This study was supported by grants from the National Natural Science Foundation of China (No. 30900667) and the Technology Research and Development Foundation of Nanjing Medical University (No. 08NMUZ021).

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Authors and Affiliations

  1. Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing, 210011, China

    Xiang Wang, Kashish Dhawan, Jie Lin, Ashwini Satpathy, Guozhong Ji, Zhining Fan & Faming Zhang

  2. Department of Pathology, Second Affiliated Hospital of Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing, 210011, China

    Ping Zhang

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  1. Xiang Wang
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  2. Kashish Dhawan
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  3. Jie Lin
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  4. Ashwini Satpathy
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  5. Ping Zhang
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  6. Guozhong Ji
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  7. Zhining Fan
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  8. Faming Zhang
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Corresponding author

Correspondence to Faming Zhang.

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X. Wang and K. Dhawan contributed equally to this work.

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Wang, X., Dhawan, K., Lin, J. et al. Pathological feature of a giant ileal Meckel’s diverticulum with ectopic gastric mucosa. Clin J Gastroenterol 3, 92–96 (2010). https://doi.org/10.1007/s12328-010-0144-2

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  • DOI: https://doi.org/10.1007/s12328-010-0144-2

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