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Achalasia, chronic sensory neuropathy, and N-type calcium channel autoantibodies: beneficial response to IVIG

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Abstract

Autoimmune gastrointestinal dysmotility (AGID) can result from paraneoplastic onconeuronal antibodies. Patients may present with regional hypomotility anywhere along the gastrointestinal tract. We report a case of a woman who developed an insidious sensory neuropathy and achalasia. She was found to have a high-titer of N-type voltage gated-calcium channel (VGCC) antibodies. She demonstrated clinical and electrophysiological improvement of her neuropathy, as well as improvement of her swallowing and gait, after treatment with intravenous immunoglobulins.

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Authors and Affiliations

  1. Department of Neurology, Lahey Clinic, 41 Mall Road, Burlington, MA, 01805, USA

    Hugh J. McMillan & Jayashri Srinivasan

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  1. Hugh J. McMillan
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  2. Jayashri Srinivasan
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Correspondence to Jayashri Srinivasan.

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McMillan, H.J., Srinivasan, J. Achalasia, chronic sensory neuropathy, and N-type calcium channel autoantibodies: beneficial response to IVIG. Clin J Gastroenterol 3, 78–82 (2010). https://doi.org/10.1007/s12328-010-0140-6

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  • DOI: https://doi.org/10.1007/s12328-010-0140-6

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