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Malignant potential of hepatic angiomyolipoma: case report and literature review

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Abstract

Hepatic angiomyolipoma (AML) is known as a rare benign tumor with invasive growth. In the past, some of these tumors were misdiagnosed as hepatocellular carcinomas, because of the similar pattern on imaging studies. Recently, correct diagnoses have been increasing, with the development of HMB-45 immunohistochemical staining, and it appears that the majority of these tumors behave as benign tumors. However, there are not a few cases which have resulted in fatal courses because of recurrence and metastasis of the tumor. The clinical features and signs of the malignant potential of this tumor are unknown; thus, the management and treatment of the tumor are still controversial. Here in this article, we report a case of hepatic AML which showed a size increase of 175% in 1 year, and portal vein thrombosis detected by angiography. During a follow up of 3 years after a curative hepatic lobectomy, no metastasis or recurrence was seen. Review of the literature suggests that portal vein thrombosis could be one of the markers of the malignant potential and transformation of this tumor. Therefore, in this paper, we recommend surgical treatment of hepatic AML in which there is a strong suspicion of portal vein thrombosis.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-757, Chuo-ku, Niigata, Niigata, 951-8122, Japan

    Kenya Kamimura, Minoru Nomoto & Yutaka Aoyagi

  2. Department of Gastroenterology and Hepatology, Shinrakuen Hospital, 3-11 Shindoriminami 3 chome, Nishiku Niigata, Niigata, 950-2087, Japan

    Akihiko Oosaki, Satoshi Sugahara & Shigeki Mori

  3. Department of Surgery, Shinrakuen Hospital, 3-11 Shindoriminami 3 chome, Nishiku Niigata, Niigata, 950-2087, Japan

    Tetsuya Moroda & Osamu Satoh

  4. Department of Pathology, Shinrakuen Hospital, 3-11 Shindoriminami 3 chome, Nishiku Niigata, Niigata, 950-2087, Japan

    Takashi Morita & Kakuhei Kimura

  5. Department of Radiology, Shinrakuen Hospital, 3-11 Shindoriminami 3 chome, Nishiku Niigata, Niigata, 950-2087, Japan

    Takashi Kamura

Authors
  1. Kenya Kamimura
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  2. Akihiko Oosaki
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  3. Satoshi Sugahara
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  4. Shigeki Mori
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  5. Tetsuya Moroda
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  6. Osamu Satoh
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  7. Takashi Morita
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  8. Kakuhei Kimura
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  9. Takashi Kamura
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  10. Minoru Nomoto
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  11. Yutaka Aoyagi
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Correspondence to Kenya Kamimura.

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Kamimura, K., Oosaki, A., Sugahara, S. et al. Malignant potential of hepatic angiomyolipoma: case report and literature review. Clin J Gastroenterol 3, 104–110 (2010). https://doi.org/10.1007/s12328-010-0136-2

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  • DOI: https://doi.org/10.1007/s12328-010-0136-2

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