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A case in which danaparoid sodium was effective for portal venous thrombosis developed after endoscopic injection sclerotherapy for esophageal varices

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Abstract

We report a case of hepatitis C type liver cirrhosis with portal venous thrombosis in which danaparoid sodium was very effective. The patient developed portal venous thrombosis, esophageal ulcer, and esophageal stenosis at the same time after sclerotherapy. Since it was confirmed by abdominal computed tomography that there was no portal venous thrombosis before sclerotherapy, development of the thrombosis was considered to be associated with sclerotherapy. The patient was treated with balloon dilation therapy for esophageal stenosis, and with anticoagulation therapy using danaparoid sodium for portal venous thrombosis. The portal venous thrombosis disappeared 4 weeks after the treatment. Despite the condition of esophageal ulcer being caused by sclerotherapy, the patient was safely treated without any adverse effects and complications, and the clinical course has been good. It was indicated that danaparoid sodium was an anticoagulant unlikely to cause adverse effects such as hemorrhage and might be an effective drug for treatment of portal venous thrombosis.

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References

  1. Balfour GW, Stewart TG. Case of enlarged spleen complicated with ascites, both depending upon varicose dilatation and thrombosis of the portal vein. Edinburgh Med J. 1869;14:589–98.

    Google Scholar 

  2. Valla DC, Condat B. Portal vein thrombosis in adults; pathophysiology, pathogenesis and management. J Hepatol. 2000;32:365–71.

    Article  Google Scholar 

  3. Yazaki Y, Okuno K, Ishikawa Y, Yamada M, Ono M, Ohta T, et al. Studies on various esophageal lesions due to paravariceal injections of 5% ethanolamine oleate during endoscopic injection sclerotherapy of esophageal varices (in Japanese with English abstract). Nippon Shokakinaisikyo Gakkai Zasshi (Gastroenterol Endosc). 1986;28:2257–67.

    Google Scholar 

  4. Nomura H, Katsuramaki T, Mizuguchi T, Nishimori H, Kikuchi H, Hirata K. A case of portal vein thrombosis successfully treated with danaparoid sodium after splenectomy for giant splenomegaly by idiopathic portal hypertension (IPH) (in Japanese with English abstract). Nippon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc). 2003;64:705–9.

    Article  Google Scholar 

  5. Miyamoto Y, Oho K, Sakamoto Y, Sakai K, Kumamoto M, Tayama C, et al. Complications of EIS and EVL, and their managements (in Japanese with English abstract). Rinsho Shokaki Naika (Clinical Gastroenterol). 2002;17:1235–43.

    Google Scholar 

  6. Nakagawa M, Nonaka Y, Horibe T, Ookubo K, Kawai T, Kakutani H, et al. Four cases of portal vein thrombus after endoscopic injection sclerotherapy (in Japanese with English abstract). Shokaki Naisikyo no Sinpo (Prog Dig Endosc). 1990;36:270–4.

    Google Scholar 

  7. Belli L, Sansalone CV, Aseni P, Romani F, Rondinara G. Portal thrombosis in cirrhotics—a retrospective analysis. Ann Surg. 1986;203:286–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bizollon T, Bissuel F, Detry L, Trepo C. Fibrinolytic therapy for portal vein thrombosis. Lancet. 1991;337:1416.

    Article  CAS  PubMed  Google Scholar 

  9. Wilde MI, Markham A. Danaparoid—a review of its pharmacology and clinical use in the management of heparin-induced thrombocytopenia. Drugs. 1997;54:903–24.

    Article  CAS  PubMed  Google Scholar 

  10. Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention. Chest. 2004;126:311S–37S.

    Article  CAS  PubMed  Google Scholar 

  11. Meuleman DG. Orgaran (Org 10172): its pharmacological profile in experimental models. Haemostasis. 1992;22:58–65.

    CAS  PubMed  Google Scholar 

  12. Yokota K, Ishizu H, Kondo Y, Okada K, Masuko H, Yokota R. A case of portal vein thrombosis successfully treated with danaparoid sodium after splenectomy for hypersplenism (in Japanese with English abstract). Nippon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc). 2005;66:899–903.

    Article  Google Scholar 

  13. Shudo R, Yazaki Y, Sugawara K, Honda M. Treatment by danaparoid sodium for portal venous thrombosis (in Japanese with English abstract). Nippon Shokakibyo Gakkai Zasshi (JJSG). 2007;104:205–12.

    Google Scholar 

  14. Iba T, Kidokoro A, Fukunaga M, Nagakari K, Suda M, Yoshikawa S, et al. Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin. Intensive Care Med. 2005;31:1101–08.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Kurosawa Hospital, 4-1 Odori Minami, Obihiro, 080-0010, Japan

    Ryushi Shudo

  2. Digestive Disease Center, Kobayashi Hospital, Kitami, Japan

    Yasuyuki Yazaki & Mitsunori Honda

  3. Kitami Digestive Clinic, Kitami, Japan

    Kenji Sugawara

Authors
  1. Ryushi Shudo
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  2. Yasuyuki Yazaki
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  3. Mitsunori Honda
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  4. Kenji Sugawara
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Correspondence to Ryushi Shudo.

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Shudo, R., Yazaki, Y., Honda, M. et al. A case in which danaparoid sodium was effective for portal venous thrombosis developed after endoscopic injection sclerotherapy for esophageal varices. Clin J Gastroenterol 1, 110–115 (2008). https://doi.org/10.1007/s12328-008-0019-y

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  • DOI: https://doi.org/10.1007/s12328-008-0019-y

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