Abstract
Osteonecrosis is a major complication in patients with ulcerative colitis (UC). It appears most commonly in the femoral head, but sometimes occurs in the proximal humerus or femoral condyle. A 27-year-old Japanese woman presented with severe pain in the left knee in 2006. Osteonecrosis was found in the left lateral femoral condyle, and osteochondral autografting was performed. Ten and a half years prior to this episode, at the age of 17 years, she had been diagnosed as having UC, and after 18 months of medication, she had undergone total colectomy. A total prednisolone dose of 3020 mg had been administered before the operation, but the true pathogenesis—i.e. idiopathic or steroid-associated osteonecrosis—had not been determined at that time. The osteonecrosis occurred long after prednisolone therapy had been discontinued, and the total dose of prednisolone was not considered to be unusually high. In this case, osteochondral autografting was ultimately required for treatment of the osteonecrosis. However, conservative therapy is indicated for early-stage cases and should result in a good course. We report this case to draw attention to this relatively rare complication of UC and to facilitate early detection of similar lesions.
Similar content being viewed by others
References
Munakata A, Hatada Y, Yao T. Analysis of adverse effects of steroid therapy to inflammatory bowel disease. In: Annual report of the research committee of inflammatory bowel disease (in Japanese with English abstract). The Ministry of Health and Welfare of Japan. 1995; pp. 67–70.
Klingenstein G, Levy RN, Kornbluth A, Shah AK, Present DH. Inflammatory bowel disease-related osteonecrosis: report of a large series with a review of the literature. Aliment Pharmacol Ther. 2005;21:243–9.
Vakil N, Sparberg M. Steroid-related osteonecrosis in inflammatory bowel disease. Gastroenterology. 1989;96:62–7.
Gorczynski C, Meislin R. Osteonecrosis of the distal femur. Bull Hosp Jt Dis. 2006;63:145–52.
Madsen PV, Anderson G. Multifocal osteonecrosis related to steroid treatment in a patient with ulcerative colitis. Gut. 1994;35:132–4.
Sasaki T, Yagi T, Monji J, Yasuda K, Masuda T, Fukuzawa M, et al. Steroid-induced osteonecrosis of the femoral condyle—a clinical study of 18 knees in ten patients—(in Japanese with English abstract). Nippon Seikeigeka Gakkai Zasshi (J Jpn Orthop Assoc). 1986;60:361–72.
Gardeniers JM. ARCO committee on terminology and staging; Report of the committee-meeting at Santiago de Compostela. ARCO Newsl. 1993;5:79–82.
Ito K, Inuo-Nakayama M, Matsumoto M, Kubokawa M, Sadamoto Y, Kubo H, et al. Steroid-induced osteonecrosis in refractory ulcerative colitis. Fukuoka Igaku Zasshi. 2005;96:5–10.
Lafforgue P. Pathophysiology and natural history of avascular necrosis of bone. Joint Bone Spine. 2006;73:500–7.
Patel DV, Breazeale NM, Behr CT, Warren RF, Wickiewicz TL, O’Brien SJ. Osteonecrosis: current clinical concepts. Knee Surg Sports Traumatol Anthrosc. 1998;6:2–11.
Takao M, Sugano N, Nishii T, Miki H, Yoshikawa H. Spontaneous regression of steroid-related osteonecrosis of the knees. Clin Orthop Relat Res. 2006;452:210–5.
Aglietti P, Insall JN, Buzzi R, Deshamps G. Idiopathic osteonecrosis of the knee: aetiology, prognosis and treatment. J Bone Joint Surg. 1983;65:588–97.
Acknowledgments
We would like to thank Dr. Tamon Asano and Dr. Jun-ichi Hashimoto from the Department of Orthopedics for helpful advice.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Takeda, H., Nishise, S., Fujishima, S. et al. Osteonecrosis of the lateral femoral condyle in a patient with ulcerative colitis: report of a case. Clin J Gastroenterol 1, 93–96 (2008). https://doi.org/10.1007/s12328-008-0015-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12328-008-0015-2