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Table 2 Summary of pharmacokinetic results for CU+ 50, CU+ 100, and TUR 1800

From: Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

Formulation Cmax (ng/ml) 90% CI Relative absorption based on Cmax data Tmax (h) t1/2 (h) AUC0–6 (ng/ml h) 90% CI Relative absorption based on AUC0–6 data AUC0–12 (ng/ml h) 90% CI Relative absorption based on AUC0–12 data
Curcumin
 TUR 1800 9.85 ± 6.82 1 8 9.45 ± 5.25 15.43 ± 30.77 1 40.21 ± 44.98 1
 CU+ 50 28.36 ± 31.21* 212.66–389.60 103.62* 3* 5.33 ± 3.70* 86.53 ± 90.33* 362.46–867.41 201.86* 119.12 ± 120.81* 199.05–440.83 106.64*
 CU+ 100 54.11 ± 40.11* 392.77–767.85 98.85* 3* 3.97 ± 2.27* 160.99 ± 112.64* 629.30–1726.37 187.62* 251.12 ± 164.55* 403.54–966.41 112.41*
Demethoxycurcumin
 TUR 1800 3.20 ± 1.40 1 3 8.37 ± 5.66 6.42 ± 5.91 1 10.37 ± 10.04 1
 CU+ 50 4.33 ± 4.91 104.93–174.79 48.75* 3 6.53 ± 5.25 9.35 ± 13.81 99.29–213.67 52.44* 12.19 ± 16.92 84.12–164.30 42.32*
 CU+ 100 7.98 ± 5.65* 186.36–337.84 45.16* 3 3.60 ± 3.68 20.28 ± 15.46* 185.78–526.61 56.30* 28.42 ± 21.96* 172.24–428.26 48.89*
Bisdemethoxycurcumin
 TUR 1800 2.15 ± 1.05 1 2 3.24 ± 1.39 4.89 ± 2.82 1 6.38 ± 5.04 1
 CU+ 50 1.05 ± 1.19+ 30.86–77.04 17.55* 8+ 0.49 ± 1.17+ 2.62–38.50 3.62 1.46 ± 3.28+ 11.26–46.72 8.26*
 CU+ 100 1.15 ± 1.04+ 33.48–84.55 9.58* 5+ 0.82 ± 1.20+ 7.10–36.47 2.90 2.09 ± 2.11+ 18.49–56.61 5.82*
Tetrahydrocurcumin
 TUR 1800 5.38 ± 3.63 1 4.5 11.92 ± 7.60 7.88 ± 12.19   1 10.28 ± 16.86 1
 CU+ 50 13.98 ± 13.63* 184.37–366.04 93.52* 3* 4.89 ± 3.67* 40.81 ± 41.12* 301.11–890.97 186.47* 52.55 ± 57.19* 327.02–799.37 184.06*
 CU+ 100 26.24 ± 21.34* 348.33–669.98 86.96* 3* 5.25 ± 3.05* 81.54 ± 57.15* 552.03–1879.20 183.33* 115.44 ± 80.58* 649.28–1863.39 197.99*
Total curcuminoids
 TUR 1800 15.65 ± 9.41 1 5 9.04 ± 7.34 33.21 ± 43.34 1 66.57 ± 64.71 1
 CU+ 50 43.83 ± 48.20* 203.73–384.89 100.81* 3* 3.88 ± 2.04* 133.24 ± 138.50* 276.61–581.74 144.41* 182.65 ± 182.82* 196.42–383.29 98.78*
 CU+ 100 86.98 ± 62.94* 401.02–770.05 100.03* 3* 4.29 ± 3.95* 274.35 ± 169.57* 534.48–1282.65 149.04* 419.14 ± 248.98* 434.96–911.44 113.33*
  1. Data expressed as geometric least squares mean (Cmax, AUC) or arithmetic mean (t1/2) ± standard deviation and Tmax expressed as median. N = 24 for TUR1800, N = 23 for CU+ 50, N = 21 for CU+ 100
  2. AUC area under the curve, CU+ Curcuwin Ultra+, SD standard deviation, TUR turmeric extract
  3. *P value < 0.05, CU+ significant over TUR 1800
  4. +P value < 0.05, TUR 1800 significant over CU+ 
  5. P value < 0.05, CU+ 100 significant over CU+ 50