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Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis



The gold standard surgical therapy for patients with clinical stage I non-small cell lung cancer (NSCLC) is lobectomy with mediastinal lymph node dissection. Meanwhile, segmentectomy has emerged as an alternative choice with the advantage of fewer postoperative complications. The acceptance of this procedure remains controversial, and conflicting results exist in the retrospective trials.


The aim of this meta-analysis was to analyze the survival outcomes of lobectomy versus segmentectomy in clinical stage I NSCLC.


A computerized literature search was done on published trials in PubMed, Embase, and the Cochrane Library to June 2019 to identify clinical trials. Lung cancer-specific survival (LCSS) and overall survival (OS) were measured as outcomes. Statistical analysis was performed in the Meta-analysis Revman 5.3 software.


A systematic literature search was conducted including seven studies. In this meta-analysis, the LCSS and OS in the lobectomy group were linked to a markedly lower trend in comparison to the segmentectomy group without significant statistical difference (P > 0.05), indicating that lobectomy confers an equivalent survival outcome compared with segmentectomy.


No significant differences were found in survival outcomes between lobectomy and segmentectomy. Further large-scale, prospective, randomized trials are needed to explore reasonable surgical treatments for early-stage lung cancer.

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No funding was received for this study. The Journal’s Rapid Service Fee was funded by the authors.

Compliance with Ethics Guidelines

Ethics approval was not required for this meta-analysis.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

Jian Feng and Li-Feng Wang have made substantial contributions to conception and design of the study, written the manuscript; Ting-Yue Han and Yue Wan searched literature, extracted data from the collected literature and analysed the data; Bing-Hui Chen revised the manuscript; All authors approved the final version of the manuscript.


Jian Feng, Li-Feng Wang, Ting-Yue Han, Yue Wang, Xiu-Yu Wu, Feng Lv, Yang Liu and Bing-Hui Chen have nothing to disclose.

Data Availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Corresponding author

Correspondence to Bing-Hui Chen.

Additional information

Jian Feng, Li-Feng Wang, Ting-Yue Han contributed equally to this paper.

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Feng, J., Wang, LF., Han, TY. et al. Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis. Adv Ther 38, 4130–4137 (2021).

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  • Lobectomy
  • Meta-analysis
  • Non-small cell lung cancer
  • Segmentectomy