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Serratus Anterior Plane Block Combined with General Analgesia and Patient-Controlled Serratus Anterior Plane Block in Patients with Breast Cancer: A Randomized Control Trial



Anterior serratus muscle plane block is a novel regional block technique for blockade of the sensory plane of the lateral cutaneous branch of the intercostal nerve (T2–T9), which effectively relieves the pain of patients and improves the quality of recovery. This study aimed to observe the early effectiveness and safety of serratus anterior plane block combined with general anesthesia and patient-controlled serratus anterior plane block in early postoperative recovery in breast cancer.


The study involved a total of 84 patients undergoing radical mastectomy in our hospital. The patients were randomly divided into three groups: the serratus anterior block + general anesthesia + patient-controlled serratus anterior plane block group (PCSAPB group), the serratus anterior block + general anesthesia + patient-controlled intravenous analgesia group (PCIA group), and the general anesthesia + PCIA group (control group), with n = 28 cases in each group.


The visual analogue scale (VAS) scores of the three groups were compared before and after the operation (P < 0.001), and the anxiety visual analogue scale (AVAS) scores after operation were compared among the three groups (P < 0.001). The total number of postoperative analgesic pumps in the PCSAPB group was significantly lower than that in the control group (P < 0.05). The incidence of adverse reactions in the three groups was statistically significant (P < 0.05).


The combination of anterior serratus plane block and general anesthesia and patient-controlled anterior serratus plane block reduced pain and adverse events, alleviating anxiety, improving the quality of early postoperative recovery among patients with breast cancer after modified radical mastectomy.

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We thank the participants of the study.


No funding or sponsorship was received for this study or publication of this article. The Rapid Service Fee was funded by the authors.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authors’ Contributions

Ying-Kun Xiao was responsible for the design of the study, writing the first draft of the paper and part of the data analysis; Shou-Zhang She was responsible for clinical data collection and statistical analysis of patients; Li-Xin Xu was responsible for postoperative rehabilitation and functional evaluation of patients; Bin Zheng was responsible for guidance for the project design and article review.


All authors, including Ying-Kun Xiao, Shou-Zhang She, Li-Xin Xu and Bin Zheng, and their immediate families have not received any financial payments or other benefits from any commercial entity related to the subject of this article.

Compliance with Ethics Guidelines

All procedures performed in studies involving human participants were in accordance with the ethical standard of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

This study was approved by the ethics committee of the Guangzhou First People’s Hospital (No. K-2020-065-01). All patients and their families voluntarily participated in the study and signed the informed consent form.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Correspondence to Ying-Kun Xiao or Bin Zheng.

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Xiao, YK., She, SZ., Xu, LX. et al. Serratus Anterior Plane Block Combined with General Analgesia and Patient-Controlled Serratus Anterior Plane Block in Patients with Breast Cancer: A Randomized Control Trial. Adv Ther 38, 3444–3454 (2021).

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  • Analgesia
  • Anterior serratus plane block
  • Breast cancer
  • Early recovery quality
  • General anesthesia
  • Patient
  • Self-control