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Cost-Effectiveness Analysis of Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Metastatic Colorectal Cancer in the USA



Recently the phase 3 BEACON trial showed that the combination of encorafenib, cetuximab, and binimetinib versus cetuximab and irinotecan/FOLFIRI improved overall survival in pre-treated patients with metastatic colorectal cancer (mCRC) with BRAF V600E mutation. However, whether the benefits of these therapies justify their high costs has not been estimated in the USA. The purpose of this study was to evaluate the cost-effectiveness of BEC (binimetinib, encorafenib, and cetuximab), EC (encorafenib and cetuximab), and CI/CF (cetuximab with irinotecan or FOLFIRI) in patients with BRAF V600E-mutated mCRC after first- and second-line therapy.


A Markov model was constructed to determine the costs and effects of BEC, EC, and CI/CF on the basis of BEACON trial outcomes data. Health outcomes were measured in life years (LYs), quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs). Deterministic and probabilistic sensitivity analyses characterized parameters influencing cost-effectiveness. Subgroup analyses were conducted as well.


The QALYs gained in BEC, EC, and CI/CF were 0.62, 0.54, and 0.40, respectively. BEC resulted in ICERs of $883,895.73/QALY and $1,646,846.14/QALY versus CI/CF and EC, respectively. Compared with CI/CF, the ICER was $435,449.88/QALY in EC. The most sensitive parameters in the comparison among the three arms were the utilities of progressive disease and progression-free survival. Probabilistic sensitivity analyses showed that the probability of BEC and EC being cost-effective was 0%. In subgroup analyses, the ICER remained above the willingness-to-pay threshold of $150,000 per QALY.


BEC and EC were not cost-effective regimens for patients with pre-treated mCRC with BRAF V600E mutation.

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This manuscript, including the journal’s Rapid Service Fee, was supported by grants from the Hunan Natural Science Foundation of China (No. 2018JJ3852). All authors had full access to all of the data in this study and took complete responsibility for the integrity and accuracy of the data.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.


Shuosha Li, Huabin Hu, Dong Ding, Youwen Zhu, Jin Huang have nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any human participant or animal study. Ethics committee approval is not required.

Data Availability

All data generated or analyzed during this study are available from the corresponding author on reasonable request.

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Corresponding author

Correspondence to Jin Huang.

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Li, S., Hu, H., Ding, D. et al. Cost-Effectiveness Analysis of Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Metastatic Colorectal Cancer in the USA. Adv Ther 38, 1650–1659 (2021).

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  • Binimetinib
  • BRAF V600E mutation
  • Cetuximab
  • Cost-effectiveness
  • Encorafenib
  • Metastatic colorectal cancer