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Glucocorticoid and Breviscapine Combination Therapy Versus Glucocorticoid Alone on Sudden Sensorineural Hearing Loss in Patients with Different Audiometric Curves



We aimed to retrospectively analyze the therapeutic outcomes of using glucocorticoid combined with a vasodilator, breviscapine, versus glucocorticoid alone in patients with sudden sensorineural hearing loss (SSNHL) and to explore the impact on different audiometric curves.


Data from 154 patients were collected between January 2017 and December 2018. Patients received treatments of either glucocorticoid combined with breviscapine (GC + Bre) or glucocorticoid alone (GC). These two groups were stratified into low frequencies SSNHL (LF-SSNHL), high frequencies SSNHL (HF-SSNHL), all frequencies SSNHL (AF-SSNHL), and total deafness SSNHL (TD-SSNHL) subgroups according to their corresponding audiograms. The hearing level was evaluated by pure tone audiometry, and hearing recovery was calculated by comparing the pure tone average (PTA) at pretreatment and 4 weeks after therapy.


Hearing recovery was significantly greater for GC + Bre than GC-only treatment in the AF-SSNHL and TD-SSNHL subgroups (P < 0.05) and to a lesser extent in the LF-SSNHL and HF-SSNHL subgroups (P > 0.05). Logistic regression analysis also showed a favorable outcome for SSNHL in the GC + Bre group (odds ratio 2.848, P < 0.05).


Treating SSNHL using glucocorticoid combined with breviscapine could be more beneficial than using glucocorticoid alone, especially for patients with AF-SSNHL and TD-SSNHL.

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We thank the participants of the study.


This research was funded by the National Natural Science Foundation of China (No. 81771015) and the Shanghai Municipal Education Commission/Gaofeng Clinical Medicine Grant Support (No. 20152526) to Yanmei Feng.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

Zhong Zheng wrote the manuscript. Ying Shen, Liang Xia analysed data. Hongmin Wu, Huiqun Zhou, Xulan Tang, Lili Meng, Hui Wang, Yaqin Wu collected data. Haibo Shi, Shankai Yin gave suggestions on the data acquisition and analysis. Yanmei Feng and Zhengnong Chen designed and supervised the research. All authors reviewed the manuscript.


Zhong Zheng, Ying Shen, Liang Xia, Hongmin Wu, Huiqun Zhou, Xulan Tang, Lili Meng, Hui Wang, Yaqin Wu, Haibo Shi, Shankai Yin, Yanmei Feng and Zhengnong Chen have nothing to disclose. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Compliance with Ethics Guidelines

The study protocol was approved and implemented according to the ethical standards of the Shanghai Jiaotong University Affiliated Sixth People’s Hospital ethics committee. Information of patients was anonymized and deidentified prior to analysis. The progress was conducted in accordance with the spirit of the Helsinki Declaration. All participants provided written informed consent for their inclusion in the database and the use of their data for research purposes.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Corresponding authors

Correspondence to Yanmei Feng or Zhengnong Chen.

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Zheng, Z., Shen, Y., Xia, L. et al. Glucocorticoid and Breviscapine Combination Therapy Versus Glucocorticoid Alone on Sudden Sensorineural Hearing Loss in Patients with Different Audiometric Curves. Adv Ther 37, 4959–4968 (2020).

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  • Breviscapine
  • Glucocorticoid
  • Pure tone average
  • Vasodilator
  • Sudden sensorineural hearing loss