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Correction to: Adv Ther (2020) 37:3234–3245 https://doi.org/10.1007/s12325-020-01375-1
In the original article, there is incorrect text has published as “The hemodialysis clearance, elimination fraction percentage, and amount of amenamevir removed were 37.8 mL/min, 28.1%, and 132.0 μg, respectively”. The correct text is “The hemodialysis clearance, elimination fraction percentage, and amount of amenamevir removed were 41.4 mL/min, 30.7%, and 7919 μg, respectively”.
The incorrect text has published as “There was no correlation between CLHD and Kt/V (A), but a strong negative correlation between EP and Kt/V (r = − 0.75) (C) was found, whereas the amount removed was positively correlated with Kt/V (r = 0.55) (E)”. The correct text is “There was no correlation between CLHD and Kt/V (A), but a strong negative correlation between EP and Kt/V (r = − 0.77) (C) was found, whereas the amount removed was positively correlated with Kt/V (r = 0.58) (E)”.
Original Table
Table 4 Hemodialysis parameters of amenamevir and its major metabolite R5 (n = 9)
Amenamevir | R5 | |||||
|---|---|---|---|---|---|---|
Mean (SD) | Median | Min–max | Mean (SD) | Median | Min–max | |
Hemodialysis clearance (mL/min) | 37.8 (5.3) | 37.5 | 30.9–48.0 | 46.5 (4.4) | 45.0 | 41.4–56.2 |
Hemodialysis clearance normalized with dialyzer surface area (mL/min/m2) | 22.7 (5.4) | 22.8 | 15.1–32.3 | 28.2 (7.4) | 27.6 | 18.2–40.8 |
Elimination fraction percentage (%) | 28.1 (5.1) | 27.4 | 22.2–36.6 | 34.5 (4.7) | 32.5 | 29.6–42.9 |
Removed amount (μg) | 132.0 (54.2) | 131.6 | 43.4–236.8 | 65.1 (28.7) | 69.6 | 23.7–121.4 |
Corrected Table
Table 4 Hemodialysis parameters of amenamevir and its major metabolite R5 (n = 9)
Amenamevir | R5 | |||||
|---|---|---|---|---|---|---|
Mean (SD) | Median | Min–max | Mean (SD) | Median | Min–max | |
Hemodialysis clearance (mL/min) | 41.4 (5.0) | 39.6 | 35.7–52.2 | 49.8 (4.6) | 49.3 | 45.3–60.0 |
Hemodialysis clearance normalized with dialyzer surface area (mL/min/m2) | 24.9 (5.9) | 24.9 | 17.0–35.0 | 30.1 (7.9) | 30.2 | 19.7–43.3 |
Elimination fraction percentage (%) | 30.7 (4.8) | 29.3 | 25.5–38.6 | 36.8 (4.5) | 35.6 | 32.3–44.7 |
Removed amount (μg) | 7919 (3253) | 7894 | 2602–14,210 | 3905 (1722) | 4177 | 1419–7282 |
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Tsuruoka, S., Endo, T., Seo, M. et al. Correction to: Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialysis Patients. Adv Ther 37, 4758–4764 (2020). https://doi.org/10.1007/s12325-020-01489-6
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DOI: https://doi.org/10.1007/s12325-020-01489-6