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Effectiveness of Atorvastatin in the Treatment of Asymptomatic Heart Failure After Myocardial Infarction: A Clinical Study

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Abstract

Introduction

Silent heart failure after myocardial infarction has not been effectively treated. Atorvastatin has certain efficacy in the treatment of heart failure. Our clinical study aimed to investigate the effectiveness of atorvastatin in patients with asymptomatic heart failure after myocardial infarction.

Methods

A total of 162 patients with asymptomatic heart failure after myocardial infarction in our hospital from August 2018 to August 2019 were randomly divided into the observation group (81 cases were treated with atorvastatin on the basis of routine therapy) and the control group (81 cases were treated with routine symptomatic treatment). The clinical curative effect, the level of related inflammatory cytokines, cardiac function index, and vascular endothelial function were compared between the two groups.

Results

Before intervention, there was no significant difference in tumor necrosis factor (TNFα), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), plasma N-terminal B-type natriuretic peptide (NT-ProBNP), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), asymmetric dimethyarginine (ADMA), activity of nitric oxide synthase (NOS), nitric oxide (NO) and flow-mediated dilation (FMD) between the two groups. After intervention, TNFα, hs-CRP, IL-6, NT-ProBNP, LVEF, LVEDD, LVESD, LVPWT, ADMA, NOS, NO, and FMD were improved in both groups. The clinical curative effect, TNFα, hs-CRP, IL-6, NT-ProBNP, LVEF, LVEDD, LVESD, LVPWT, ADMA, NOS, NO, and FMD in the observation group showed significantly greater results than those in the control group (P < 0.05).

Conclusion

Atorvastatin exerted a great effect in treating asymptomatic heart failure after myocardial infarction, which can evidently reduce the level of related inflammatory cytokines, improve cardiac function, and regulate vascular endothelial function. Hence, atorvastatin is considered a valid and alternative approach in clinical practice.

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Acknowledgements

We thank all participants in this study. Thank you to all the patients and their families who signed the consent.

Funding

No funding was received for the study or publication of this article.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

DW and XHY contributed to the conception and design of the study; LB and XRC performed the experiments, JDZ collected and analyzed data; DW and XHY wrote the manuscript; All authors reviewed and approved the final version of the manuscript.

Disclosures

Dong Wang, Long Bai, Xiao-Ran Cui, Xiao-Hong Yang and Ji-Dong Zhang have nothing to disclose.

Compliance with Ethics Guidelines

The study protocol was approved by the Ethics Committee of the Second Hospital of Hebei Medical University. Written informed consent was obtained from all the study subjects before enrollment. The study was performed in accordance with the declaration of Helsinki 1964 and its later amendments.

Data Availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. The Sixth Department of Cardiovascular Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

    Dong Wang, Long Bai, Xiao-Ran Cui, Xiao-Hong Yang & Ji-Dong Zhang

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  1. Dong Wang
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  2. Long Bai
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  3. Xiao-Ran Cui
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  5. Ji-Dong Zhang
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Corresponding author

Correspondence to Xiao-Hong Yang.

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Wang, D., Bai, L., Cui, XR. et al. Effectiveness of Atorvastatin in the Treatment of Asymptomatic Heart Failure After Myocardial Infarction: A Clinical Study. Adv Ther 37, 4649–4659 (2020). https://doi.org/10.1007/s12325-020-01441-8

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  • DOI: https://doi.org/10.1007/s12325-020-01441-8

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