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Profile of Cardiovascular Disease Patients Who are Diagnosed with COPD in a Smoking-Cessation Unit



Cardiovascular diseases (CVDs) and chronic obstructive pulmonary disease (COPD) have similar prevalence rates and risk factors, and both frequently occur in the same patient. The primary objective of the study was to evaluate the rate of COPD patients among subjects with some form of CVD referring to a smoking cessation unit. The secondary objective was to analyze the demographic and clinical profile of these subjects and to identify independent factors potentially associated with COPD.


Observational, prospective study involving 132 patients with smoking habits, and some form of CVD, referring to the smoking cessation unit at the Pulmonology Department of the University Hospital of Cáceres, Spain, between October 2015 and March 2017.


A total of 58 patients (43.9%) were diagnosed with COPD. Main CVDs were: ischemic heart disease (76.5%), chronic heart failure (24.8%), peripheral arterial disease (18.5%), and atrial fibrillation (7.6%). Independent factors were: pack-years (> 30 versus < 30; odds ratio, OR 5.3; 95% CI 1.3–21.4); forced expiratory volume in the first second (OR 0.9; 95% CI 0.9–1.0); chronic heart failure (yes versus no; OR 4.7; 95% CI 1.3–16.4); and modified Medical Research Council (mMRC) dyspnea (2–3 versus 0; OR 18.7; 95% CI 1.9–182.0).


Four of ten patients with some form of CVD also experience COPD. Dyspnea, airflow limitation, smoking habits, and chronic heart failure were significant factors associated with COPD in patients with CVD. Smoking cessation units are useful to improve the diagnosis of COPD in these patients. Further prospective studies with a greater cohort of patients are required to corroborate the present results and to enhance the knowledge of the clinical profile of these patients.

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We thank the participants of the study.


This study was funded by a “Fellowship, Non-Restriction” sponsorship from Laboratorios ROVI, S.A. The Rapid Service Fee was funded by Laboratorios ROVI, S.A.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Author Contributions

Juan Antonio Riesco Miranda participated in the conception and design of the study, review of the bibliography analysis, and interpretation of the study’s results. He also drafted and revised the document and agrees with the final version. María Hidalgo participated in data collection. She also drafted and revised the document and agrees with the final version. David Chipayo participated in data collection. He also drafted and revised the document and agrees with the final version. José Javier Gómez Barrado participated in the conception and design of the study. He also drafted and revised the document and agrees with the final version. Fernando Zaragozá participated in the work of scientific advisory expertise in the preparation of the document.


Juan A. Riesco, María Hidalgo, David Chipayo, José J. Gómez, and Fernando Zaragozá have nothing to disclose.

Compliance with Ethics Guidelines

All patients signed the written informed consent to participate in the study. Procedures were approved by the ethics committee of the University Hospital of Cáceres, in accordance with the Declaration of Helsinki.

Data Availability

The data stored from this study are on a database created for the study. They are not publicly available but are available from the corresponding author on reasonable request.

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Correspondence to Juan A. Riesco.

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Riesco, J.A., Hidalgo, M., Chipayo, D. et al. Profile of Cardiovascular Disease Patients Who are Diagnosed with COPD in a Smoking-Cessation Unit. Adv Ther 37, 3562–3570 (2020).

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  • Cardiovascular disease
  • COPD
  • Patients
  • Profile