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The Relationship Between White Adipose Tissue Inflammation and Overweight/Obesity in Chinese Female Breast Cancer: A Retrospective Study

Abstract

Introduction

This study aims to investigate the relationship between breast white adipose tissue (WAT) inflammation and being overweight or obese, menopausal status, and metabolic syndrome-related indicators in breast cancer patients as well as the association between adipocyte size and the severity of WAT inflammation and body mass index (BMI).

Methods

The crown-like structures (CLS-B) formed by macrophages surrounding dying or dead adipocytes can be used to identify breast WAT inflammation. In this study, breast WAT and fasting blood from 136 Chinese women with breast cancer were collected for analysis. Cluster of differentiation 68 (CD68) immunohistochemical staining was performed to identify CLS-B, and the adipocyte size was measured by hematoxylin and eosin staining.

Results

The results showed that breast WAT inflammation usually occurs in overweight/obese breast cancer patients, and the severity of inflammation is positively correlated with adipocyte hypertrophy. We did not observe a direct association between WAT inflammation and menopausal status. In addition, the presence of WAT inflammation is associated with abnormalities in circulating factors associated with metabolic syndrome such as higher serum lipid, glucose, and C-reactive protein levels.

Conclusion

Overweight/obese breast cancer patients may be more prone to breast WAT inflammation and may be associated with abnormalities in circulatory markers associated with metabolic syndrome.

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Acknowledgements

Thanks for the support from all funding.

Funding

Medical Science and Technology Development Foundation, Nanjing Department of Health (YKK18083); Medical Science Technology Innovation Platform Project of Nanjing Health Committee (ZDX16006); Jiangsu Biobank of Clinical Resources (BM2015004); National Human Genetic Resources Sharing Service Platform (2005DKA21300). No funding or sponsorship was received for the publication of this article; the journal’s Rapid Service Fee was funded by the authors.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Yi-Xin Zhao, Yu-Lu Sun, Jia-Hui Ye, Yin Zhang, Xian-Biao Shi, Jing-Mei Wang, Hong-Yan Wu, Wei-Jie Zhang, and Yong-Zhong Yao have nothing to disclose.

Compliance with Ethics Guidelines

This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of Nanjing Drum Tower Hospital. All participants signed informed consent to publish their data.

Data Availability

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.

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Correspondence to Yong-Zhong Yao.

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Zhao, YX., Sun, YL., Ye, JH. et al. The Relationship Between White Adipose Tissue Inflammation and Overweight/Obesity in Chinese Female Breast Cancer: A Retrospective Study. Adv Ther 37, 2734–2747 (2020). https://doi.org/10.1007/s12325-020-01368-0

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  • DOI: https://doi.org/10.1007/s12325-020-01368-0

Keywords

  • Breast neoplasms
  • Crown-like structures
  • Inflammation
  • Obesity
  • White adipose tissue