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Efficacy and Tolerability of Prucalopride in Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis



Adequate bowel preparation is a vital determinant for the success of colonoscopy. However, individuals who undergo bowel preparation for colonoscopy can experience major discomfort. To solve this problem, adding prucalopride to the prepared solution may reduce intake volume, decreasing discomfort and side effects. We performed meta-analyses and systematic review of available randomized controlled trials.


Meta-analyses were conducted to evaluate the overall relative risk and 95% confidence intervals in the combined studies for the assessment of primary outcome, which is the efficacy of bowel preparation with the addition of prucalopride.


Four randomized controlled trials involving 581 patients were included. When data were pooled for all patients in two non-inferiority studies, no significant difference in the quality of bowel preparation was observed between patients receiving prucalopride plus bowel preparation solution at a lower volume and those receiving the existing solution (relative risk: 0.94; 95% confidence interval: 0.86–1.03). The effects of prucalopride on acceptability, adverse events, adenoma detection rate, and polyp detection rate did not significantly differ from those of traditional solutions.


The combination of prucalopride and bowel preparation solution at a lower volume has similar effects on bowel preparation, and its use did not increase the occurrence of adverse effects.

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No funding or sponsorship was received for this study or publication of this article. The Rapid Service Fee was funded by the authors.


All authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

Design and supervision: Ji Taek Hong. Data extraction and study review: Ji Taek Hong, Sung-Wook Park, and Seok-Pyo Shin. Data analysis: Sung-Wook Park and Ji Taek Hong. Visualization: Ji Taek Hong. Writing-original draft: Ji Taek Hong and Sung-Wook Park Approval of the final manuscript: all authors. Corresponding author: Ji Taek Hong.


The authors Sung-Wook Park, Seok-Pyo Shin, and Ji Taek Hong have nothing to disclose. Ji Taek Hong’s current affiliation is the Department of Internal Medicine, College of Medicine, Mokdong Hospital, Ewha Womans University, Seoul, Korea.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.

Data Availability

All data and materials used in this study are freely available. References have been provided.

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Correspondence to Ji Taek Hong.

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Park, SW., Shin, SP. & Hong, J.T. Efficacy and Tolerability of Prucalopride in Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis. Adv Ther 37, 2507–2519 (2020).

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  • Bowel preparation
  • Polyethylene glycol
  • Prucalopride