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Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database

Advances in Therapy volume 37, pages 2236–2245 (2020)Cite this article

Abstract

Introduction

Breast cancer (BC) and lung cancer (LuC) are common malignancies. The survival of patients with metachronous second primary malignancy (MSPM) of BC and LuC after a first primary of BC and LuC remains unclear.

Methods

Data of patients with BC and LuC, with or without MSPM of BC and LuC, who were diagnosed from 2000 to 2014, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The baseline characteristics of the different groups were compared using chi-square tests. The survival curves were compared using the log-rank test. Survival analysis was also performed in other malignancies with data extracted from the SEER database using the same method.

Results

Significant differences in most of the demographics and clinicopathological factors were found between the groups. Patients with LuC with an MSPM of BC (LuC2BC) exhibited better survival than those with LuC (P < 0.001), while patients with BC with an MSPM of LuC (BC2LuC) exhibited worse survival than those with BC (P < 0.001). A similar trend was found in other malignancies. Prostate cancer (PC) followed by thyroid cancer (TC) (PC2TC) and TC followed by PC (TC2PC) did not show an obvious survival trend against their index malignancy (IM).

Conclusions

MSPM benefits the IM prognosis if the survival rate of MSPM is better than that of the IM and vice versa. However, the situation is somewhat confusing when the survival differences between MSPM and IM are minimal.

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Acknowledgements

We thank Prof. Yiping He from the Department of Pathology, Duke University Medical Center for critical revision of the manuscript.

Funding

Kefeng Lei was supported by a grant from the Natural Science Foundation of Zhejiang Province of China (grant number LY18H160039). The sponsor also partially funded the journal's Rapid Service Fee.

Editorial Assistance

This manuscript was edited for proper English language, grammar, punctuation, spelling, and overall style by Stefanie M. and Courey A. at American Journal Experts. This assistance was funded by the study sponsor.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Miaochun Zhong, Xianghong He, and Kefeng Lei have nothing to disclose.

Compliance with Ethics Guidelines

All SEER data were accessed with approval from the SEER database and, as such, this article does not contain any studies with human participants or animals performed by any of the authors.

Data Availability

The datasets analyzed in the current study are available from the corresponding author on reasonable request.

Author information

Author notes

  1. Miaochun Zhong, Xianghong He, and Kefeng Lei contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China

    Miaochun Zhong

  2. Public Basic Courses Department, Guangdong University of Science and Technology, Dongguan, Guangdong, China

    Xianghong He

  3. Department of General Surgery, The 7th Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China

    Kefeng Lei

Authors
  1. Miaochun Zhong
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  2. Xianghong He
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  3. Kefeng Lei
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Corresponding author

Correspondence to Kefeng Lei.

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Zhong, M., He, X. & Lei, K. Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database. Adv Ther 37, 2236–2245 (2020). https://doi.org/10.1007/s12325-020-01322-0

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  • DOI: https://doi.org/10.1007/s12325-020-01322-0

Keywords

  • Breast cancer
  • Lung cancer
  • Metachronous second primary malignancy
  • Oncology
  • SEER
  • Survival