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SOFA Score Can Effectively Predict the Incidence of Sepsis and 30-Day Mortality in Liver Transplant Patients: A Retrospective Study

Advances in Therapy volume 36, pages 645–651 (2019)Cite this article

Abstract

Introduction

This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA).

Methods

A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general information, biochemical findings, and postoperative 30-day mortality of these patients were statistically analyzed.

Results

The SOFA scores, C-reactive protein (CRP), and procalcitonin (PCT) at postoperative day (POD) 3, 5, and 7 were significantly higher in the sepsis group than in the non-sepsis group, and the differences were statistically significant. Receiver operating characteristic (ROC) curve showed that SOFA scores at POD 1, 3, 5, and 7 had higher sensitivity and specificity in predicting the incidence of sepsis within 30 days. The difference in 30-day survival rate between patients with SOFA scores of > 5 and patients with SOFA scores of ≤ 5 at POD 1–7 was statistically significant (P < 0.05).

Conclusion

SOFA scores at POD 1–7 can effectively predict the incidence of sepsis and 30-day mortality in liver transplant patients on the basis of CRP and PCT.

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Acknowledgements

We thank the participants of the study.

Funding

No funding or sponsorship was received for this study or publication of this article. The article processing charges were funded by the authors.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Xiao-Wen Wang, Xing-Guo Niu, Jin-Xiu Li, Si-Sen Zhang, and Xian-Fa Jiao declare that they have no conflict of interest.

Compliance with Ethics Guidelines

This study was conducted in accordance with the 1964 declaration of Helsinki and its later amendments and was approved by the Ethics Committee of People’s Hospital of Zhengzhou. Written informed consent was obtained from all participants.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Intensive Care Unit, People’s Hospital of Zhengzhou, Zhengzhou, 450000, China

    Xiao-Wen Wang, Xing-Guo Niu, Jin-Xiu Li, Si-Sen Zhang & Xian-Fa Jiao

Authors
  1. Xiao-Wen Wang
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  2. Xing-Guo Niu
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  3. Jin-Xiu Li
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  5. Xian-Fa Jiao
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Corresponding author

Correspondence to Xian-Fa Jiao.

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Wang, XW., Niu, XG., Li, JX. et al. SOFA Score Can Effectively Predict the Incidence of Sepsis and 30-Day Mortality in Liver Transplant Patients: A Retrospective Study. Adv Ther 36, 645–651 (2019). https://doi.org/10.1007/s12325-019-0889-z

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  • DOI: https://doi.org/10.1007/s12325-019-0889-z

Keywords

  • Liver transplantation
  • Mortality
  • Sepsis
  • SOFA score