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The Relationship Between Homocysteine, Blood Pressure Variability, and Left Ventricular Hypertrophy in Patients with Essential Hypertension: An Observational Study

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This study aimed to investigate the relationship between homocysteine (Hcy) and blood pressure variability (BPV) and the relationship between Hcy and left ventricular hypertrophy (LVH) in 102 patients with essential hypertension.


The 102 patients were divided into the Hcy < 10 μmol/L group (n = 47) and the Hcy ≥ 10 μmol/L group (n = 55) according to Hcy concentration. The differences between Hcy and BPV and Hcy and LVH were compared between the two groups. Finally, the correlations between Hcy and BPV and between Hcy and LVH were analyzed.


The results showed that there were significant differences between Hcy and BPV and between Hcy and LVH in the two groups. Hcy correlated positively with the coefficient of variation in nighttime diastolic blood pressure and night systolic blood pressure standard deviation (nDBPSD), with correlation coefficients of 0.331 and 0.303 (P < 0.001). At the same time, Hcy correlated positively with interventricular septal thickness and left ventricular posterior wall thickness, which were indicators of LVH, with correlation coefficients of 0.350 and 0.352 (P < 0.001).


There was a correlation between Hcy and BPV and between Hcy and LVH. Attention should also be paid to blood Hcy and BPV for patients with essential hypertension.

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We thank all participants of the study.


The study was supported by Yulin Science and Technology Research Project (No: 161034), Guangxi Science and Technology Plan Project (No: 1598011-2) and PRIME China Post-Single Group Study (XP China SAS, No: 12-396). The Rapid Service Fee was funded by the authors.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

Bei-You Lin and Ping Li contributed equally to this work.


Bei-You Lin, Ping Li, Xiao-Dan Wu, Hao Li, and Zhi-Yu Zeng have nothing to disclose.

Compliance with Ethics Guidelines

The scheme adopted in this study was based on the principles of the Helsinki Declaration and approved by the Ethics Committee of the Yulin First Hospital. All participants provided written consent to participate in the study.

Data Availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Correspondence to Zhi-Yu Zeng.

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Lin, BY., Li, P., Wu, XD. et al. The Relationship Between Homocysteine, Blood Pressure Variability, and Left Ventricular Hypertrophy in Patients with Essential Hypertension: An Observational Study. Adv Ther 37, 381–389 (2020).

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