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A Prospective Study of Comparing the Application of Two Generation Scoring Systems in Patients with Acute Cerebral Infarction



This study aims to compare the value of acute physiologic and chronic health evaluation scoring systems (APACHE II and APACHE III) among patients with acute cerebral infarction.


The APACHE II and APACHE III scores were determined in 399 patients with acute cerebral infarction within 24 h of admission in order to investigate their predictive value for prognosis in acute cerebral infarction. The area under the ROC curve was used to measure the ability of two scoring systems in predicting the prognosis of patients, and the area under the curve of the two scoring systems was compared.


The APACHE II and APACHE III scoring systems demonstrated good predictive value for prognosis in acute cerebral infarction, and the areas under the receiver operating characteristic were 0.808 and 0.818, respectively. There was no significant difference in the area under the curve between these two scoring systems.


Both the APACHE II and APACHE III scoring systems had good predictive value for prognosis in acute cerebral infarction, and there was no obvious difference between these two systems. Preference was suggested for APACHE II.

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No funding or sponsorship was received for this study or publication of this article. The Rapid Service Fee was funded by the authors.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.


Qun-Xi Li, Xiao-Jing Zhao, Yan-Bo Peng, Da-Li Wang, Xiao-Liu Dong, Hai-Yan Fan, Rui-Ying Chen, Jiang Zhang, Li Zhang and Jian Liu have nothing to disclose.

Compliance with Ethics Guidelines

This study was conducted in accordance with the declaration of Helsinki and compliance with Ethics Guidelines. This study was conducted with approval from the Ethics Committee of the Affiliated Hospital of North China University of Science and Technology. Written informed consent was obtained from the participants or their guardians.

Data Availability

All data generated or analyzed during this study are included in this published article/as supplementary information files.

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Corresponding author

Correspondence to Xiao-Jing Zhao.

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Li, QX., Zhao, XJ., Peng, YB. et al. A Prospective Study of Comparing the Application of Two Generation Scoring Systems in Patients with Acute Cerebral Infarction. Adv Ther 36, 3071–3078 (2019).

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  • Acute cerebral infarction
  • Acute physiologic and chronic health evaluation
  • Illness assessment
  • Prognosis