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Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1%

Advances in Therapy volume 36, pages 2712–2722 (2019)Cite this article

Abstract

Purpose

To compare the efficacy of bromfenac 0.09% and dexamethasone 0.1% in the treatment of anterior chamber inflammation after uncomplicated cataract surgery.

Methods

Seventy-six patients with senile cataracts and no other ocular comorbidities who underwent uneventful phacoemulsification were randomized 1:1 to receive dexamethasone ophthalmic suspension 0.1% or bromfenac ophthalmic solution 0.09% for 2 weeks. All patients were examined on the day before surgery and postoperatively at day 1, 3, 7, 9, 11, 14 and 30. Laser flare photometry was used to quantify anterior chamber inflammation and optical coherence tomography to measure macular thickness.

Results

Bromfenac was as effective as dexamethasone in reducing inflammation in the anterior chamber of the eye. Laser flare increased the day after surgery and progressively decreased after starting the treatment with no statistically significant difference between dexamethasone and bromfenac at all time points. Visual acuity improved steadily after surgery in both groups. Mean macular thickness was similar in both the dexamethasone and bromfenac arms at 1 month.

Conclusions

Short-term therapy with topical bromfenac alone is as effective as dexamethasone in low-risk cataract surgery patients.

Trial Registration

ClinicalTrials.gov # NCT03317847; EudraCT # 2016-004358-14.

Funding

Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy.

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Acknowledgements

The authors thank all patients for kindly participating in the study.

Funding

The study was sponsored by the Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy, who also funded the Rapid Service Fees.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure

Marco Coassin, Michele De Maria, Valentina Mastrofilippo, Luca Braglia, Luca Cimino, Antonio Sartori and Luigi Fontana have nothing to declare.

Compliance with Ethics Guidelines

The study protocol was approved by the local ethics committee (Comitato Etico dell’Area Vasta Emilia Nord) and the trial was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all patients.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

Authors and Affiliations

  1. Ophthalmology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Marco Coassin, Michele De Maria, Valentina Mastrofilippo, Antonio Sartori & Luigi Fontana

  2. Ophthalmology, University Campus Bio-Medico, Rome, Italy

    Marco Coassin

  3. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy

    Michele De Maria

  4. Clinical Trials and Statistics Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Luca Braglia

  5. Ocular Immunology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Luca Cimino

Authors
  1. Marco Coassin
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  2. Michele De Maria
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  3. Valentina Mastrofilippo
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  4. Luca Braglia
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  5. Luca Cimino
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  6. Antonio Sartori
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  7. Luigi Fontana
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Corresponding author

Correspondence to Marco Coassin.

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Cite this article

Coassin, M., De Maria, M., Mastrofilippo, V. et al. Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1%. Adv Ther 36, 2712–2722 (2019). https://doi.org/10.1007/s12325-019-01076-4

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  • DOI: https://doi.org/10.1007/s12325-019-01076-4

Keywords

  • Cataract surgery
  • Laser flare photometry
  • Non-steroidal anti-inflammatory drugs
  • Ophthalmology