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Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology

Advances in Therapy volume 36, pages 1–18 (2019)Cite this article

Abstract

Introduction

Silodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Objective

We aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the treatment of LUTS.

Methods

PubMed and Web of Science were queried with the terms: ‘silodosin’ in combination (AND) with the terms ‘lower urinary tract symptoms’, ‘LUTS’, ‘pathophysiology’, ‘symptoms’ OR ‘therapy’. Studies published in the last 10 years (2007–2017) in adults and core clinical journals in English were included.

Results

Silodosin 8 mg once-daily was superior to placebo in improving IPSS total score, voiding subscore, storage subscore and QoL score, and at least as effective as tamsulosin 0.4 mg once-daily in all the efficacy analyses. In addition, studies assessing the effect on urodynamic parameters showed that silodosin determined a higher improvement in the bladder outlet obstruction index compared to other alpha1 adrenergic receptor antagonists. Concerning the safety profile, long-term data (after 9 months of treatment) confirmed the limited effect of silodosin on the cardiovascular and gastrointestinal systems. Although ejaculatory disorders represented the main complaint of patients taking silodosin, the discontinuation rate due to this condition remained low even in a long-term follow-up study (7.5%). Encouraging findings showed that silodosin may be administered as a medical expulsive therapy for promoting spontaneous stone passage of distal ureteral stones < 10 mm, to relieve LUTS in patients who underwent prostate cancer brachytherapy and to increase the likelihood of successful trials without a catheter in patients experiencing acute urinary retention.

Conclusion

Silodosin is one of the drugs approved for the treatment of BPH, being highly effective in improving not only LUTS but also urodynamic parameter impairments secondary to BPH. Moreover, it has shown efficacy as medical expulsive therapy for distal ureteral stones in previous prospective randomized trials.

Funding

Sponsorship for this study and article processing charges were funded by Recordati.

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References

  1. Issa MM, Fenter TC, Black L, et al. An assessment of the diagnosed prevalence of diseases in men 50 years of age or older. Am J Manag Care. 2006;12:S83–9.

    PubMed  Google Scholar 

  2. Oelke M, Burger M, Castro-Diaz D, et al. Diagnosis and medical treatment of lower urinary tract symptoms in adult men: applying specialist guidelines in clinical practice. BJU Int. 2011;110:710–8.

    Article  Google Scholar 

  3. McVary KT, Roehrborn CG, Avins AL, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011;185:1793–803.

    Article  Google Scholar 

  4. De Nunzio C, Ahyai S, Autorino R, et al. Benign prostatic hyperplasia and lower urinary tract symptoms: research priorities. Eur Urol. 2011;60:1205–6.

    Article  Google Scholar 

  5. Parsons JK. Commentary on BPH and public health–have we lost the forest through the trees? J Urol. 2008;179:S81.

    Article  Google Scholar 

  6. Isaacs JT. Importance of the natural history of benign prostatic hyperplasia in the evaluation of pharmacologic intervention. Prostate Suppl. 1990;3:1–7.

    CAS  Article  Google Scholar 

  7. Netto NR Jr, de Lima ML, Netto MR, D’Ancona CA. Evaluation of patients with bladder outlet obstruction and mild international prostate symptom score followed up by watchful waiting. Urology. 1999;53:314–6.

    Article  Google Scholar 

  8. Kupelian V, Wei JT, O’Leary MP, et al. Nocturia and quality of life: results from the Boston area community health survey. Eur Urol. 2012;61:78–84.

    Article  Google Scholar 

  9. Tikkinen KA, Johnson TM 2nd, Tammela TL, et al. Nocturia frequency, bother, and quality of life: how often is too often? A population-based study in Finland. Eur Urol. 2010;57:488–96.

    Article  Google Scholar 

  10. Gratzke C, Bachmann A, Descazeaud A, et al. EAU guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. Eur Urol. 2015;67:1099–109.

    Article  Google Scholar 

  11. Tatemichi S, Kobayashi K, Maezawa A, et al. Alpha1-adrenoceptor subtype selectivity and organ specificity of silodosin (KMD-3213) [article in Japanese]. Yakugaku Zasshi. 2006;126:209–16.

    CAS  PubMed  Google Scholar 

  12. Akiyama K, Noto H, Nishizawa O, et al. Effect of KMD-3213, an alpha1A-adrenoceptor antagonist, on the prostatic urethral pressure and blood pressure in male decerebrate dogs. Int J Urol. 2001;8:177–83.

    CAS  Article  Google Scholar 

  13. Schilit S, Benzeroual KE. Silodosin: a selective alpha1A-adrenergic receptor antagonist for the treatment of benign prostatic hyperplasia. Clin Ther. 2009;31:2489–502.

    CAS  Article  Google Scholar 

  14. Chapple CR, Montorsi F, Tammela TL, et al. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. Eur Urol. 2011;59:342–52.

    CAS  Article  Google Scholar 

  15. Marks LS, Gittelman MC, Hill LA, et al. Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies. J Urol. 2009;181:2634–40.

    CAS  Article  Google Scholar 

  16. Kawabe K, Yoshida M, Homma Y. Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. BJU Int. 2006;98:1019–24.

    CAS  Article  Google Scholar 

  17. Yu HJ, Lin AT, Yang SS, et al. Non-inferiority of silodosin to tamsulosin in treating patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). BJU Int. 2011;108:1843–8.

    CAS  Article  Google Scholar 

  18. Capitanio U, Salonia A, Briganti A, Montorsi F. Silodosin in the management of lower urinary tract symptoms as a result of benign prostatic hyperplasia: who are the best candidates. Int J Clin Pract. 2013;67:544–51.

    CAS  Article  Google Scholar 

  19. Nasu K, Moriyama N, Kawabe K, et al. Quantification and distribution of alpha 1-adrenoceptor subtype mRNAs in human prostate: comparison of benign hypertrophied tissue and non-hypertrophied tissue. Br J Pharmacol. 1996;119:797–803.

    CAS  Article  Google Scholar 

  20. Shibata K, Foglar R, Horie K, et al. KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol Pharmacol. 1995;48:250–8.

    CAS  PubMed  Google Scholar 

  21. Martin DJ, Angel I, Arbilla S. Functional uroselectivity. Eur Urol. 1998;33(Suppl 2):12–8.

    CAS  Article  Google Scholar 

  22. Moriyama N, Akiyama K, Murata S. KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur J Pharmacol. 1997;331:39–42.

    CAS  Article  Google Scholar 

  23. Goi Y, Tomiyama Y, Nomiya M, Sagawa K, Aikawa K, Yamaguchi O. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction. J Urol. 2013;190:1116–22.

    CAS  Article  Google Scholar 

  24. Inoue S, Saito M, Tsounapi P, et al. Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat. BJU Int. 2012;110:E118–24.

    CAS  Article  Google Scholar 

  25. Aizawa N, Watanabe D, Fukuhara H, et al. Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet obstruction. Neurourol Urodyn. 2018. https://doi.org/10.1002/nau.23547 (Epub ahead of print).

    Article  PubMed  Google Scholar 

  26. Hennenberg M, Strittmatter F, Beckmann C, et al. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. PLoS ONE. 2012;7:e50904.

    CAS  Article  Google Scholar 

  27. Matsukawa Y, Gotoh M, Komatsu T, Funahashi Y, Sassa N. Hattori R Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study. J Urol. 2013;189:S117–21.

    CAS  Article  Google Scholar 

  28. Yamanishi T, Mizuno T, Tatsumiya K, et al. Urodynamic effects of silodosin, a new alpha 1A-adrenoceptor selective antagonist, for the treatment of benign prostatic hyperplasia. Neurourol Urodyn. 2010;29:558–62.

    CAS  PubMed  Google Scholar 

  29. Fusco F, Creta M, Longo N, Persico F, Franco M, Mirone V. Silodosin 8 mg improves benign prostatic obstruction in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: results from an explorative clinical study. BMC Urol. 2018;18:12.

    Article  Google Scholar 

  30. Fusco F, Palmieri A, Ficarra V, et al. α1-Blockers improve benign prostatic obstruction in men with lower urinary tract symptoms: a systematic review and meta-analysis of urodynamic studies. Eur Urol. 2016;69:1091–101.

    CAS  Article  Google Scholar 

  31. Fusco F, Creta M, Imperatore V, et al. Benign prostatic obstruction relief in patients with lower urinary tract symptoms suggestive of benign prostatic enlargement undergoing endoscopic surgical procedures or therapy with alpha-blockers: a review of urodynamic studies. Adv Ther. 2017;34:773–83.

    Article  Google Scholar 

  32. Osman NI, Chapple CR, Tammela TL, Eisenhardt A, Oelke M. Open-label, 9-month extension study investigating the uro-selective alpha-blocker silodosin in men with LUTS associated with BPH. World J Urol. 2015;33:697–706.

    CAS  Article  Google Scholar 

  33. Marks LS, Gittelman MC, Hill LA, Volinn W, Hoel G. Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: a 9-month, open-label extension study. Urology. 2009;74:1318–22.

    Article  Google Scholar 

  34. Yamanishi T, Kaga K, Fuse M, Shibata C, Kamai T, Uchiyama T. Six-year follow up of silodosin monotherapy for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: what are the factors for continuation or withdrawal? Int J Urol. 2015;22(12):1143–8.

    CAS  Article  Google Scholar 

  35. Ding H, Du W, Hou ZZ, Wang HZ, Wang ZP. Silodosin is effective for treatment of LUTS in men with BPH: a systematic review. Asian J Androl. 2013;15:121–8.

    CAS  Article  Google Scholar 

  36. Novara G, Tubaro A, Sanseverino R, et al. Systematic review and meta-analysis of randomized controlled trials evaluating silodosin in the treatment of non-neurogenic male lower urinary tract symptoms suggestive of benign prostatic enlargement. World J Urol. 2013;31:997–1008.

    Article  Google Scholar 

  37. Novara G, Chapple CR, Montorsi F. A pooled analysis of individual patient data from registrational trials of silodosin in the treatment of non-neurogenic male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). BJU Int. 2014;114:427–33.

    CAS  PubMed  Google Scholar 

  38. Montorsi F, Gandaglia G, Chapple C, Cruz F, Desgrandchamps F, Llorente C. Effectiveness and safety of silodosin in the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia: a European phase IV clinical study (SiRE study). Int J Urol. 2016;23:572–9.

    CAS  Article  Google Scholar 

  39. Matsukawa Y, Funahashi Y, Takai S, et al. Comparison of silodosin and naftopidil for efficacy in the treatment of benign prostatic enlargement complicated by overactive bladder: a randomized, prospective study (SNIPER study). J Urol. 2017;197:452–8.

    CAS  Article  Google Scholar 

  40. Eisenhardt A, Schneider T, Cruz F. Oelke M Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies. World J Urol. 2014;32:1119–25.

    Article  Google Scholar 

  41. Montorsi F. Profile of silodosin. Eur Urol Suppl. 2010;9:491–5.

    CAS  Article  Google Scholar 

  42. McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349:2387–98.

    CAS  Article  Google Scholar 

  43. Roehrborn CG, Siami P, Barkin J, et al. The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study. J Urol. 2008;179:616–21.

    CAS  Article  Google Scholar 

  44. Roehrborn CG, Siami P, Barkin J, et al. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol. 2010;57:123–31.

    CAS  Article  Google Scholar 

  45. Matsukawa Y, Takai S, Funahashi Y, et al. Effects of withdrawing α1-blocker from combination therapy with α1-blocker and 5α-reductase inhibitor in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a prospective and comparative trial using urodynamics. J Urol. 2017;198:905–12.

    CAS  Article  Google Scholar 

  46. Kaplan SA, Roehrborn CG, Abrams P, Chapple CR, Bavendam T, Guan Z. Antimuscarinics for treatment of storage lower urinary tract symptoms in men: a systematic review. Int J Clin Pract. 2011;65:487–507.

    CAS  Article  Google Scholar 

  47. Matsukawa Y, Takai S, Funahashi Y, Kato M, Yamamoto T, Gotoh M. Long-term efficacy of a combination therapy with an anticholinergic agent and an α1-blocker for patients with benign prostatic enlargement complaining both voiding and overactive bladder symptoms: a randomized, prospective, comparative trial using a urodynamic study. Neurourol Urodyn. 2017;36:748–54.

    CAS  Article  Google Scholar 

  48. MacDiarmid SA, Hill LA, Volinn W, Hoel G. Lack of pharmacodynamic interaction of silodosin, a highly selective alpha1a-adrenoceptor antagonist, with the phosphodiesterase-5 inhibitors sildenafil and tadalafil in healthy men. Urology. 2010;75:520–5.

    Article  Google Scholar 

  49. Buono R, Briganti A, Freschi M, et al. Silodosin and tadalafil have synergistic inhibitory effects on nerve-mediated contractions of human and rat isolated prostates. Eur J Pharmacol. 2014;744:42–51.

    CAS  Article  Google Scholar 

  50. Yoshida T, Kinoshita H, Shimada S, Taguchi M, Matsuda T. Comparison of silodosin monotherapy vs silodosin with tadalafil add-on therapy in patients with benign prostatic hyperplasia. Urology. 2017;106:159.

    Google Scholar 

  51. Canda AE, Turna B, Cinar GM, Nazli O. Physiology and pharmacology of the human ureter: basis for current and future treatments. Urol Int. 2007;78:289–98.

    Article  Google Scholar 

  52. Park HK, Choi EY, Jeong BC, Kim HH, Kim BK. Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureter. Urol Res. 2007;35:325–9.

    CAS  Article  Google Scholar 

  53. Kobayashi S, Tomiyama Y, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H. Effects of four different alpha(1)-adrenoceptor antagonists on alpha-adrenoceptor agonist-induced contractions in isolated mouse and hamster ureters. J Smooth Muscle Res. 2009;45:187–95.

    Article  Google Scholar 

  54. Rajpathy J, Aswathaman K, Sinha M, Subramani S, Gopalakrishnan G, Kekre NS. An in vitro study on human ureteric smooth muscle with the alpha1-adrenoceptor subtype blocker, tamsulosin. BJU Int. 2008;102:1743–5.

    Article  Google Scholar 

  55. Davenport K, Timoney AG, Keeley FX Jr. Effect of smooth muscle relaxant drugs on proximal human ureteric activity in vivo: a pilot study. Urol Res. 2007;35:207–13.

    CAS  Article  Google Scholar 

  56. Sasaki S, Tomiyama Y, Kobayashi S, Kojima Y, Kubota Y, Kohri K. Characterization of α1-adrenoceptor subtypes mediating contraction in human isolated ureters. Urology. 2011;77(762):e13–7.

    Google Scholar 

  57. Kobayashi S, Tomiyama Y, Hoyano Y, et al. Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage. J Urol. 2010;183:357–61.

    CAS  Article  Google Scholar 

  58. Villa L, Buono R, Fossati N, Rigatti P, Montorsi F, Benigni F, Hedlund P. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters. Br J Pharmacol. 2013;169:230–8.

    CAS  Article  Google Scholar 

  59. Tsuzaka Y, Matsushima H, Kaneko T, et al. Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients. Int J Urol. 2011;18:792–5.

    CAS  Article  Google Scholar 

  60. Itoh Y, Okada A, Yasui T, et al. Efficacy of selective alpha1A adrenoceptor antagonist silodosin in the medical expulsive therapy for ureteral stones. Int J Urol. 2011;18:672–4.

    CAS  PubMed  Google Scholar 

  61. Itoh Y, Okada A, Yasui T, et al. Administration of the selective alpha 1A-adrenoceptor antagonist silodosin facilitates expulsion of size 5–10 mm distal ureteral stones, as compared to control. Int Urol Nephrol. 2013;45:675–8.

    CAS  Article  Google Scholar 

  62. Sur RL, Shore N, L’Esperance J, et al. Silodosin to facilitate passage of ureteral stones: a multi-institutional, randomized, double-blinded, placebo-controlled trial. Eur Urol. 2015;67(9):59–64.

    Google Scholar 

  63. Kumar S, Jayant K, Agrawal MM, Singh SK, Agrawal S, Parmar KM. Role of tamsulosin, tadalafil, and silodosin as the medical expulsive therapy in lower ureteric stone: a randomized trial (a pilot study). Urology. 2015;85:59–63.

    Article  Google Scholar 

  64. Nickel JC, O’Leary MP, Lepor H, et al. Silodosin for men with chronic prostatitis/chronic pelvic pain syndrome: results of a phase II multicenter, double-blind, placebo controlled study. J Urol. 2011;186:125–31.

    CAS  Article  Google Scholar 

  65. Shirakawa T, Haraguchi T, Shigemura K, et al. Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized multicenter study. Int J Urol. 2013;20:903–10.

    CAS  Article  Google Scholar 

  66. Miyakita H, Yokoyama E, Onodera Y, et al. Short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia. Int J Urol. 2010;17(10):869–75.

    Article  Google Scholar 

  67. Shimizu N, Minami T, Sugimoto K, et al. Efficacy of silodosin in patients undergoing brachytherapy: a randomized trial involving a pressure flow study. World J Urol. 2014;32:1423–32.

    CAS  Article  Google Scholar 

  68. Tsumura H, Satoh T, Ishiyama H, et al. Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial. Int J Radiat Oncol Biol Phys. 2011;81:e385–92.

    CAS  Article  Google Scholar 

  69. Kumar S, Tiwari DP, Ganesamoni R, Singh SK. Prospective randomized placebo-controlled study to assess the safety and efficacy of silodosin in the management of acute urinary retention. Urology. 2013;82:171–5.

    Article  Google Scholar 

  70. Hagiwara K, Koie T, Iwamura H, et al. Efficacy and safety of silodosin and dutasteride combination therapy in acute urinary retention due to benign prostatic hyperplasia: a single-arm prospective study. Biomed Res Int. 2016;2016:4975851.

    Article  Google Scholar 

  71. Agency. EM. CHMP ASSESSMENT REPORT FOR Silodyx. Doc.Ref.: EMA/72316/2010. Procedure no. EMEA/H/C/001209. 2010 [cited] http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Public_assessment_report/human/001209/WC500074188.pdf. Accessed 13 Mar 2018.

  72. Michel MC. Alpha1-adrenoceptors and ejaculatory function. Br J Pharmacol. 2007;152:289–90.

    CAS  Article  Google Scholar 

  73. Hellstrom WJ, Sikka SC. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol. 2006;176:1529–33.

    CAS  Article  Google Scholar 

  74. Tatemichi S, Kobayashi K, Yokoi R, et al. Comparison of the effects of four α1-adrenoceptor antagonists on ejaculatory function in rats. Urology. 2012;80(486):e9–16.

    Google Scholar 

  75. Kobayashi K, Masumori N, Hisasue S, et al. Inhibition of seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers. J Sex Med. 2008;5(9):2185–90.

    Article  Google Scholar 

  76. Roehrborn CG, Kaplan SA, Lepor H, Volinn W. Symptomatic and urodynamic responses in patients with reduced or no seminal emission during silodosin treatment for LUTS and BPH. Prostate Cancer Prostatic Dis. 2011;14:143–8.

    CAS  Article  Google Scholar 

  77. Homma Y, Kawabe K, Takeda M, Yoshida M. Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia. Urology. 2010;76:1446–50.

    Article  Google Scholar 

  78. Gacci M, Ficarra V, Sebastianelli A. Impact of medical treatments for male lower urinary tract symptoms due to benign prostatic hyperplasia on ejaculatory function: a systematic review and meta-analysis. J Sex Med. 2014;11:1554–66.

    CAS  Article  Google Scholar 

  79. Capogrosso P, Serino A, Ventimiglia E, et al. Effects of silodosin on sexual function—realistic picture from the everyday clinical practice. Andrology. 2015;3:1076–81.

    CAS  Article  Google Scholar 

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Acknowledgements

Funding

Sponsorship for this study and article processing charges were funded by Recordati. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Luca Villa has received research support, consultancy and lecturer honoraria in the field of α1-adrenoceptors from Recordati. Umberto Capitanio has received research support, consultancy and lecturer honoraria in the field of α1-adrenoceptors from Recordati. Andrea Salonia has received research support, consultancy and lecturer honoraria in the field of α1-adrenoceptors from Recordati. Francesco Montorsi has received research support, consultancy and lecturer honoraria in the field of α1-adrenoceptors from Recordati. Paolo Capogrosso, Alberto Martini and Alberto Briganti have nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy

    Luca Villa, Paolo Capogrosso, Umberto Capitanio, Alberto Martini, Alberto Briganti, Andrea Salonia & Francesco Montorsi

  2. Università Vita-Salute San Raffaele, Milan, Italy

    Alberto Martini, Alberto Briganti, Andrea Salonia & Francesco Montorsi

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  1. Luca Villa
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  2. Paolo Capogrosso
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Villa, L., Capogrosso, P., Capitanio, U. et al. Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology. Adv Ther 36, 1–18 (2019). https://doi.org/10.1007/s12325-018-0854-2

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Keywords

  • Acute urinary retention
  • Benign prostatic hyperplasia
  • BPH
  • Brachytherapy
  • Lower urinary tract symptoms
  • LUTS
  • Silodosin
  • Ureteral stone