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The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer

Abstract

The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.

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Acknowledgements

No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole and have given final approval for the version to be published. This article was written by members of the International Head and Neck Scientific Group (http://www.IHNSG.com).

Disclosures

Fernando López, Valerie J. Lund, Carlos Suárez, Carl H. Snyderman, Nabil F. Saba, K. Thomas Robbins, Vincent Vander Poorten, Primož Strojan, William M. Mendenhall, Alessandra Rinaldo and Alfio Ferlito have nothing to disclose.

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López, F., Lund, V.J., Suárez, C. et al. The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer. Adv Ther 34, 2181–2198 (2017). https://doi.org/10.1007/s12325-017-0605-9

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Keywords

  • Endoscopic surgery
  • Histology
  • Oncology
  • Paranasal cavities
  • Radiotherapy
  • Sinonasal cancer