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Ovulation Induction is a More Effective Stimulant on Antiovarian Antibody Production than In Vitro Fertilization

Abstract

Introduction

Our aim in this study is to evaluate the effects of in vitro fertilization (IVF), including controlled ovarian hyperstimulation (COH) and the number of oocyte pick-up (OPU) procedures on the development of anti-ovarian antibodies (AOA).

Methods

To evaluate the effects of IVF procedures, namely, COH and OPU, serum samples for measuring AOA concentration levels by enzyme-linked immunosorbent assay were collected on the third day of the menstrual cycle, at the end of the COH, and after OPU.

Results

The AOA levels in IVF patients were significantly higher than the fertile control groups’. In the IVF group, neither COH nor OPU caused any increase in AOA levels when compared to the basal results. AOA levels were higher in patients with a history of 5–8 cycles of ovulation induction, before IVF treatment. There was no relationship between the basal AOA concentrations and the type of infertility, the etiology of infertility or the pregnancy outcomes, whereas there was a relationship between the AOA and the duration of infertility.

Conclusion

AOA levels of IVF patients were found to be higher than the fertile control groups’. AOA was found to be related to infertility in patients who had a longer duration of infertility and repeated ovulation induction procedures without IVF. COH and OPU during an IVF cycle did not cause an increase in AOA levels.

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Acknowledgments

No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.

Disclosures

Nezaket Kadıoğlu, Başak Güler, Sibel Özler, Sevtap Kılıç, M. Nedim Çiçek and A. Sertaç Batıoğlu have nothing to disclose.

Compliance with Ethics Guidelines

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964, as revised in 2013. Informed consent was obtained from all patients for being included in the study.

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Correspondence to Başak Güler.

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Kadıoğlu, N., Güler, B., Özler, S. et al. Ovulation Induction is a More Effective Stimulant on Antiovarian Antibody Production than In Vitro Fertilization. Adv Ther 33, 1408–1416 (2016). https://doi.org/10.1007/s12325-016-0356-z

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Keywords

  • Antiovarian antibodies
  • In vitro fertilization
  • Infertility
  • Ooocyte pick-up
  • Ovulation induction
  • Reproduction