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Does Defibrotide Induce a Delay to Polymorphonuclear Neutrophil Engraftment After Hematopoietic Stem Cell Transplantation? Observation in a Pediatric Population

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Abstract

Introduction

In recent years, defibrotide (DFT) has emerged as a promising therapy for veno-occlusive disease (VOD). The aim of this study was to investigate whether DFT prophylaxis affects neutrophil engraftment in patients undergoing hematopoietic stem cell transplantation (HSCT).

Methods

A cohort of 44 consecutive pediatric patients who underwent HSCT was retrospectively analyzed to see the role of DFT on engraftment. Patients were assigned into two groups based on the use or non-use of prophylaxis with DFT.

Results

The mean time to engraftment was statistically different between the two groups for both polymorphonuclear neutrophils (PMN) and white blood cells.

Conclusion

Our study supports the hypothesis that prophylaxis with DFT for VOD leads to a delay to the engraftment of PMN in pediatric patients that underwent HSCT.

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Acknowledgments

No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.

Conflict of interest

Natalia Maximova, Antonio Pizzol, Nagua Giurici, and Marilena Granzotto declare that they have no conflict of interest.

Compliance with ethics guidelines

This article does not contain any new studies with human or animal subjects performed by any of the authors. The study protocol was approved by the Institutional Review Board of the Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”.

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Authors and Affiliations

  1. Bone Marrow Transplant Unit, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Trieste, Italy

    Natalia Maximova, Antonio Pizzol & Nagua Giurici

  2. Laboratory Department, A.O.U. Ospedali Riuniti, Trieste, Italy

    Marilena Granzotto

Authors
  1. Natalia Maximova
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  2. Antonio Pizzol
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  3. Nagua Giurici
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  4. Marilena Granzotto
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Corresponding author

Correspondence to Natalia Maximova.

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Maximova, N., Pizzol, A., Giurici, N. et al. Does Defibrotide Induce a Delay to Polymorphonuclear Neutrophil Engraftment After Hematopoietic Stem Cell Transplantation? Observation in a Pediatric Population. Adv Ther 32, 381–386 (2015). https://doi.org/10.1007/s12325-015-0203-7

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  • DOI: https://doi.org/10.1007/s12325-015-0203-7

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