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Correlation of the Coronary Severity Scores and Mean Platelet Volume in Diabetes Mellitus

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Abstract

Introduction

It is known that mean platelet volume (MPV) increases during acute coronary syndrome. However, there are conflicting data about the importance of MPV in patients with stable coronary artery disease (CAD). This study aimed to assess relationship between MVP and the severity of coronary atherosclerosis in patients with diabetes mellitus (DM), stable CAD and normal left ventricular ejection fractions.

Methods

Thirty-three DM and 46 nonDM patients with stable CAD diagnosed by selective coronary angiography were included in the study. All angiographic variables pertinent to Gensini score (GS) and Syntax score (SS) calculation were computed by two experienced interventional cardiologists. All patients underwent echocardiographic examination. MPV and other biochemical markers were measured on admission.

Results

All patients were evaluated and it was found that both scoring systems are correlated with MPV (GS: r = 0.373, p < 0.001; SS: r = 0.385, p < 0.001). DM and nonDM groups were severally evaluated, it was found that the correlation between MPV and GS and SS increased in DM patients (GS: r = 0.638, p < 0.001; SS: r = 0.624, p < 0.001); however, no differences were identified in nonDM patients (GS: r = 0.124, p = 0.410; SS: r = 0.124, p = 0.411).

Conclusion

It is thought that high MPV levels may be an effective marker in determining the severity of CAD in patients with DM. And the high MPV level may be related with CAD pathophysiology in DM patients.

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Acknowledgments

No funding or sponsorship was received for this study or publication of this article. Dr. Albali is the guarantor for this article, and takes responsibility for the integrity of the work as a whole.

Conflict of interest

G. Abalı, O. Akpınar and N. Söylemez declare that they have no conflicts of interest.

Compliance with ethics guidelines

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 and 2008. Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Cardiology, Acıbadem University, Adana, Turkey

    G. Abalı

  2. Department of Cardiology, Adana Medline Hospital, Adana, Turkey

    O. Akpınar

  3. Department of Cardiology, State Hospital of Mersin, Mersin, Turkey

    N. Söylemez

Authors
  1. G. Abalı
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  2. O. Akpınar
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  3. N. Söylemez
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Corresponding author

Correspondence to O. Akpınar.

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Abalı, G., Akpınar, O. & Söylemez, N. Correlation of the Coronary Severity Scores and Mean Platelet Volume in Diabetes Mellitus. Adv Ther 31, 140–148 (2014). https://doi.org/10.1007/s12325-013-0081-9

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  • DOI: https://doi.org/10.1007/s12325-013-0081-9

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