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Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix

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Abstract

Introduction

Platycodi radix is a radish used in food, such as Korean kimchi, and has been shown to cause weight loss in rodents. Platycodin D is considered its active ingredient and has been shown to inhibit lipases. The authors hypothesized that platycodi radix and the platycodin D it contains inhibit angiogenesis; another mechanism for weight loss.

Methods

This study tested platycodi radix extract, platycodin D, and an extract of platycodi radix standardized to platycodin D for their ability to inhibit angiogenesis in a human adipose tissue assay. This study treated five healthy volunteers, orally, with platycodi radix extract standardized to 414 mg of platycodin D. Three volunteers were treated under fasting conditions, one volunteer with a 400 kcal meal, and one volunteer treated with a placebo. Blood was drawn over 5 hours to compare serum inhibition of the human adipose tissue angiogenesis.

Results

Platycodin radix extract, platycodin D, and platycodi radix extract standardized to platycodin D all inhibited angiogenesis. The three volunteers who consumed platycodi radix extract standardized to 414 mg of platycodin D had a 25.76% reduction in angiogenesis from baseline at 60 minutes (P<0.002), and had a statistically significant reduction in angiogenesis from 30 to 240 minutes (P<0.05 to P<0.002). The placebo decreased angiogenesis by 5.6% between 30 and 240 minutes, compared with 17.8% by the extract. The meal delayed absorption by approximately 3.5 hours.

Conclusion

Platycodi radix extract standardized to platycodin D inhibited angiogenesis in human volunteers, and paves the way for a dose-response study and a human clinical obesity trial.

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Authors and Affiliations

  1. Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA

    Emma M. Twiner, Jeffrey Gimble, Ying Yu & Frank Greenway

  2. Louisiana State University Agricultural Center, Baton Rouge, LA, 70803, USA

    Zhijun Liu

Authors
  1. Emma M. Twiner
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  2. Zhijun Liu
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  3. Jeffrey Gimble
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  4. Ying Yu
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  5. Frank Greenway
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Corresponding author

Correspondence to Frank Greenway.

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Twiner, E.M., Liu, Z., Gimble, J. et al. Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix. Adv Therapy 28, 857–865 (2011). https://doi.org/10.1007/s12325-011-0061-x

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  • DOI: https://doi.org/10.1007/s12325-011-0061-x

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