Advances in Therapy

, 25:703 | Cite as

The schizophrenia and Toxoplasma gondii connection: Infectious, immune or both?

  • Gulden Sonmez TamerEmail author
  • Devrim Dundar
  • Irem Yalug
  • Seyda Caliskan
  • Suleyman Yazar
  • Ahmet Aker
Original Research



Recent research has suggested a possible link between toxoplasmic agents and schizophrenia. We aimed to assess this by measuring Toxoplasma gondii-associated antibodies in schizophrenia patients and controls


We used a commercially available enzyme-linked immunosorbent assay (ELISA) kit to measure the level of immunoglobulin G (IgG) and IgM antibodies in serum samples from schizophrenia patients (n=40) and from a group of non-schizophrenic control subjects (n=37)


Among schizophrenic patients, 16 (40%) showed IgG seropositivity and two (5%) showed IgM seropositivity. Among the control group, five (13.5%) were found have IgG seropositivity and one (2.7%) showed IgM seropositivity. In our study we found that IgG T gondii antibodies were significantly higher in schizophrenia patients compared with controls


This study supports the theory that toxoplasmic agents may have a role in the aetiology of schizophrenia


enzyme immunoassay schizophrenia Toxoplasma gondii 


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Copyright information

© Springer Healthcare Communications 2008

Authors and Affiliations

  • Gulden Sonmez Tamer
    • 1
    • 4
    Email author
  • Devrim Dundar
    • 1
  • Irem Yalug
    • 2
  • Seyda Caliskan
    • 1
  • Suleyman Yazar
    • 3
  • Ahmet Aker
    • 2
  1. 1.Department of Clinical MicrobiologyKocaeli University, Medical FacultyKocaeliTurkey
  2. 2.Department of PsychiatryKocaeli University, Medical FacultyKocaeliTurkey
  3. 3.Department of ParasitologyErciyes University, Medical FacultyKayseriTurkey
  4. 4.Klinik Mikrobiyoloji Anabilim DaliKocaeli Universitesi Tip Fakültesi Umuttepe Kampüsü KocaeliTürkiye

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