Abstract
Opsoclonus refers to saccadic oscillations without an intersaccadic interval occurring in multiple planes. Opsoclonus mostly indicates dysfunction of the brainstem or cerebellum. We report opsoclonus induced by horizontal head-shaking without other signs of brainstem or cerebellar dysfunction in two patients with vestibular migraine (VM). The development of opsoclonus after horizontal head-shaking indicates unstable or hyperactive neural circuits between the excitatory and inhibitory saccadic premotor burst neurons in these patients with VM.
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Funding
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (No. NRF-2021R1F1A1061527).
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M–K Kim analyzed and interpreted the data and wrote the manuscript. W–H Lee, X Yang, H-J Kim, and J-Y Choi analyzed and interpreted the data and revised the manuscript. J-S Kim designed and conceptualized the study, interpreted the data, and revised the manuscript. All authors reviewed the manuscript.
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This study was approved by the Institutional Review Committee of Seoul National University Bundang Hospital (B-2208–773-701), and informed consent for case report was obtained from the patient.
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Dr. J-S Kim serves as an associate editor of Frontiers in Neuro-otology and on the editorial boards of the Journal of Clinical Neurology, Frontiers in Neuro-ophthalmology, Journal of Neuro-ophthalmology, Journal of Vestibular Research, Journal of Neurology, and Medicine. Dr. J-Y Choi serves as an associate editor in Journal of Clinical Neurology. The other authors have nothing to disclose.
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Kim, MK., Lee, WH., Yang, X. et al. Opsoclonus Induced by Head-Shaking in Vestibular Migraine. Cerebellum 23, 856–860 (2024). https://doi.org/10.1007/s12311-023-01571-z
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DOI: https://doi.org/10.1007/s12311-023-01571-z