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Urinary Symptoms and Urodynamic Findings in Patients with Spinocerebellar Ataxia

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Abstract

Urinary dysfunctions are not considered symptoms of spinocerebellar ataxias (SCAs). However, given that a patient with SCAs without a family history might be misdiagnosed as MSA-C when having urinary dysfunctions, characterization of urinary dysfunctions in SCAs is needed not only to understand SCAs but also to correctly diagnosis patients with ataxia. We retrospectively reviewed medical records of 143 patients with genetically confirmed SCA1, 2, 3, 6, 7, 17, and DRPLA. Twenty-two patients (men n = 9; age 62.1 ± 10.9; disease duration 8.2 ± 2.9 years) who had lower urinary track symptoms (LUTS) were included in this study. Six patients underwent urodynamic study (UDS), and 2 underwent uroflowmetry. LUTS was present in 1 of 11 patients with SCA1, in 4 of 51 with SCA2, in 2 of 26 with SCA3, in 3 of 20 with SCA6, in 2 of 4 with SCA7, in 8 of 26 with SCA17, and in 2 of 5 with DRPLA. Overall, urinary frequency was the most common symptom (16 patients, 72.7%) followed by voiding difficulty. In three of the 6 patients with UDS, post-micturition residuals were > 100 ml. Detrusor overactivity was noted in three patients. Detrusor areflexia was observed in one. Four patients were diagnosed with a neurogenic bladder, 3 with a storage problem, and 1 with both storage and voiding problems. Fifteen percent of the patients with SCAs had LUTS, and LUTS occurred in various types of SCAs. Our results indicate that SCAs should be considered in patients with progressive cerebellar ataxia and urinary dysfunctions.

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Authors and Affiliations

  1. Department of Neurology, Eulji University Hospital, Daejeon, South Korea

    Mihee Jang

  2. Department of Neurology, Movement Disorder Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea

    Han-Joon Kim & Beomseok Jeon

  3. Department of Neurology, Chungbuk National University Hospital, Cheongju, South Korea

    Aryun Kim

Authors
  1. Mihee Jang
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  2. Han-Joon Kim
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  3. Aryun Kim
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  4. Beomseok Jeon
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Contributions

MHJ and HJK conceived and organized the research project. MHJ, HJK, and BJ collected the data. MHJ, HJK, ARK, and BSJ analyzed the data. MHJ and HJK wrote the draft of the manuscript. ARK and BSJ made critiques for the draft. Finally, all authors approved the final version of the manuscript.

Corresponding author

Correspondence to Han-Joon Kim.

Ethics declarations

All patients provided written informed consent according to the Declaration of Helsinki. The objectives and procedures of the study were approved by the institutional review board (Seoul National University Hospital: reference number C-1712-142-909).

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

This article does not contain any studies with animals performed by any of the authors.

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Jang, M., Kim, HJ., Kim, A. et al. Urinary Symptoms and Urodynamic Findings in Patients with Spinocerebellar Ataxia. Cerebellum 19, 483–486 (2020). https://doi.org/10.1007/s12311-020-01126-6

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  • DOI: https://doi.org/10.1007/s12311-020-01126-6

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