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Regulation and Interaction of Multiple Types of Synaptic Plasticity in a Purkinje Neuron and Their Contribution to Motor Learning

The Cerebellum volume 17, pages 756–765 (2018)Cite this article

Abstract

There are multiple types of plasticity at both excitatory glutamatergic and inhibitory GABAergic synapses onto a cerebellar Purkinje neuron (PN). At parallel fiber to PN synapses, long-term depression (LTD) and long-term potentiation (LTP) occur, while at molecular layer interneuron to PN synapses, a type of LTP called rebound potentiation (RP) takes place. LTD, LTP, and RP seem to contribute to motor learning. However, each type of synaptic plasticity might play a different role in various motor learning paradigms. In addition, defects in one type of synaptic plasticity could be compensated by other forms of synaptic plasticity, which might conceal the contribution of a particular type of synaptic plasticity to motor learning. The threshold stimulation for inducing each type of synaptic plasticity and the induction conditions are different for different plasticity mechanisms, and they change depending on the state of an animal. Facilitation and/or saturation of synaptic plasticity occur after certain behavioral experiences or in some transgenic mice. Thus, the regulation and roles of synaptic plasticity are complicated. Toward a comprehensive understanding of the respective roles of each type of synaptic plasticity and their possible interactions during motor learning processes, I summarize induction conditions, modulations, interactions, and saturation of synaptic plasticity and discuss how multiple types of synaptic plasticity in a PN might work together in motor learning processes.

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Acknowledgments

The author thanks Drs. S. Kawaguchi, G. Ohtsuki, and E. Nakajima for helpful comments on the manuscript.

Funding

This work was supported by grant 17H05566 from the Ministry of Education, Culture, Sports, Science, and Technology in Japan to T.H.

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  1. Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan

    Tomoo Hirano

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Hirano, T. Regulation and Interaction of Multiple Types of Synaptic Plasticity in a Purkinje Neuron and Their Contribution to Motor Learning. Cerebellum 17, 756–765 (2018). https://doi.org/10.1007/s12311-018-0963-0

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Keywords

  • Long-term depression
  • Long-term potentiation
  • Rebound potentiation
  • Purkinje neuron
  • Motor learning
  • Synaptic plasticity
  • Parallel fiber
  • Climbing fiber